SETTING: Doheny Eye Institute, Los Angeles, California, USA.
DESIGN: Cross-sectional study.
METHODS: A Fourier-domain OCT system (RTVue) was used to scan normal eyes, eyes after myopic laser in situ keratomileusis (LASIK), and keratoconic eyes. After the corneal surfaces were delineated, the system calculated anterior and posterior corneal powers by curve fitting over the central 3.0 mm diameter area. Net corneal
power was calculated using a thick-lens formula. The repeatability of the calculations was evaluated by the pooled standard deviation of 3 measurements from the same visit. The net corneal power values were compared with standard automated keratometry measurements (IOLMaster).
RESULTS: The repeatability this website of Fourier-domain OCT net www.selleckchem.com/products/Rapamycin.html corneal power was 0.19 diopters (D), 0.26 D, and 0.30 D in the normal, post-LASIK, and keratoconus groups, respectively. The Fourier-domain OCT net corneal power was significantly lower than keratometry by a mean of -1.21 D, -2.89 D, and -3.07 D, respectively (P<.001). The anterior posterior curvature ratio was lower in post-LASIK and keratoconic eyes than in normal eyes (P<.001).
Corneal power measured by Fourier-domain OCT achieved good repeatability in all 3 groups. The repeatability was better than slower time-domain OCT systems. Because Fourier-domain OCT directly measures both anterior and posterior corneal surfaces, it may produce more consistent results than standard keratometry in post-LASIK and keratoconic eyes in which the anterior posterior corneal curvature ratios are altered by surgery or disease.”
“Background: PI3K inhibitor Personality characteristics have been associated with cocaine use. However, little is known about the mechanisms through which personality
could impact drug use. The present study investigated the cross-sectional and prospective relationships between personality dimensions (i.e., impulsivity, neuroticism) and problematic cocaine use. Reactivity to a pharmacological stressor as a potential mediator of the relationship between neuroticism and future cocaine use was also examined.
Methods: Participants were 53 cocaine-dependent individuals and 47 non-dependent controls. Subjects completed the Eysenck Personality Questionnaire (EPQ) at baseline and were administered i.v. corticotrophin releasing hormone (CRH; 1 mu g/kg). Cocaine use in the 30 days following CRH administration was measured.
Results: Cocaine-dependent individuals had higher scores on the psychoticism (i.e., impulsivity, aggression; p = 0.02) and neuroticism (p < 0.01) scales of the EPQ than non-dependent controls. Cocaine-dependent individuals also had a greater subjective stress response to CRH than controls (p < 0.01). Cocaine-dependent individuals with elevated psychoticism used significantly more cocaine over the follow-up period (p < 0.