2 vs. 4.9 log10IU/l), HBV DNA (11.4 vs. 9.8 log10IU/ml) and ALT levels (90.7 vs. 83.6 U/L). HBsAg loss could be maintained off-treatment for up to two years in six patients Opaganib with available data, two patients developed anti-HBs. A >0.5log10 reduction in HBsAg levels after 24 weeks was achieved in 6/7 (85.7%, sensitivity) patients with HBsAg loss compared to 23/93 without (24.7%) resulting in NPV of 98% (70/71), PPV of 21% (6/29) and specificity of 75% (70/93). A >1 log10 reduction in HBsAg levels after 52 weeks
was seen in 7/7 (100%, sensitivity) patients with HBsAg loss compared to 13/92 without resulting in NPV of 100%, PPV of 35% (7/20) and specificity of 86% (79/92). 20/21 patients with w52 >1log10 HBsAg reduction had also w24 >0.5log10 HBsAg. The HBsAg slope up to week 24 is significantly associated with HBsAg loss (p=0.0315). Conclusions: In HBeAg-positive CHB, HBeAg <10 PEIU/L and undetectable HBV DNA after 24 weeks of antiviral
treatment are equally predictive for W104/EoT outcomes. A >0.5log HBsAg reduction after 24 weeks of telbivudine is associated with a better on-treatment response as well as higher rate of sustained HBsAg loss after 2 years. Negative predictive values for HBsAg decrease by week 24 and 52 allow identifying patients who will not achieve HBsAg loss. Disclosures: Teerha Piratvisuth -Advisory Committees or Review Panels: Merck, Roche, Novar-tis; Grant/Research Support: Novartis, Roche, Bristol Myers Squibb, Fibrogen; Speaking and Teaching: Merck, Roche, Novartis, GlaxoSmithKline, Bristol Myers Squibb Heiner Wedemeyer – Advisory Committees or buy AZD2014 Review Panels: Transgene, MSD, Roche, Gilead, Abbott, BMS, Falk; Grant/Research Support: MSD, Novartis, Gilead, Roche, Abbott; Speaking and Teaching: BMS, MSD, Novartis, ITF Michael P. Manns – Consulting: Roche, BMS, Gilead, Boehringer Ingelheim, Novartis, MCE公司 Idenix, Achillion, GSK, Merck/MSD, Janssen, Medgenics; Grant/Research Support: Merck/MSD, Roche, Gilead, Novartis, Boehringer Ingelheim, BMS; Speaking and Teaching:
Merck/MSD, Roche, BMS, Gilead, Janssen, GSK, Novartis Mechthild E. Jung – Employment: Novartis Pharma AG Yuhong Dong – Employment: novartis Aldo Trylesinski – Employment: Novartis The following people have nothing to disclose: Karsten Wursthorn, Behrend J. Zacher Background/Aim: HBsAg quantification has been associated with response to peginterferon in HBeAg-negative CHB. The PERSEAS cohort study aimed to assess predictors of response in HBeAg-negative CHB patients treated with peginterferon-alfa-2a in routine clinical practice. Methods: PERSEAS, a prospective, multicenter, observational study in Greece enrolled 95 predominantly genotype D HBeAg-negative CHB patients who were treated with peginterferon-alfa-2a for 48 weeks. All patients were followed for 48 weeks post-treatment.