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“Nadolol and propranolol are beta-blockers used to prevent the onset of migraines. Two simple and rapid High Performance Liquid Chromatographic (HPLC) methods with ultraviolet detection were evaluated in order to establish their efficacy for detecting nadolol and propranolol hydrochloride in samples obtained from in vitro transdermal absorption

studies. Both methods were validated for specificity, linearity, precision, accuracy, limit of detection, limit of quantification and robustness. Moreover, the stability of both drugs in a buffered solution was assessed. Separation was carried out on a 250 mm Kromasil(R) C(18) column at room temperature. When nadolol was analysed, the detector response at 269 nm was found to be linear in a concentration range of

0.17 to 167 click here mu M. In the case of propranolol hydrochloride, a fixed wavelength of 291 nm for quantification corresponded with calibration lines in the range of 0.11 to 113 mu M. The limits of detection (LOD) and quantification (LOQ) were 0.058 and 0.038 M and 0.171 and 0.115 mu M for nadolol and propranolol hydrochloride, respectively. The maximum relative error and relative standard deviation detected were 5.19% and 6.08% respectively for nadolol and 3.57% and 6.44% respectively for propranolol hydrochloride. The results of robustness were highly satisfactory.”
“Structural, magnetic, and electrical properties of Bi1-xPbxFeO3 (x=0, 0.1, 0.2, and 0.3) polycrystalline prepared by solid solution route were studied. The crystal structure data obtained from x-ray diffraction indicate see more that the solid solution Bi1-xPbxFeO3 successively transforms selleck chemicals llc from rhombohedral to pseudocubic symmetry with an increase in the Pb concentration. The observed weak ferromagnetism and

ferroelectricity at room temperature indicated the multiferroic nature of Pb-doped BiFeO3 compounds. The magnetoelectric coupling was estimated by the changes in the dielectric constant with an external magnetic field. It was found that the value of magnetodielectric effect have a maximum of 0.4% for Bi0.7Pb0.3FeO3 ceramic under a magnetic field of 12 kOe at room temperature. (C) 2009 American Institute of Physics. [DOI: 10.1063/1.3079770]“
“Biofilms formed by Candida albicans, a human pathogen, are known to be resistant to different antifungal agents. Novel strategies to combat the biofilm associated Candida infections like multiple drug therapy are being explored. In this study, potential of chloroquine to be a partner drug in combination with four antifungal agents, namely fluconazole, voriconazole, amphotericin B, and caspofungin, was explored against biofilms of C. albicans. Activity of various concentrations of chloroquine in combination with a particular antifungal drug was analyzed in a checkerboard format.