Participating HIGS investigators and centres in order of contribution: Liesner, Raina, Great Ormond Street Hospital for Children NHS Trust, London, UK; Windyga, Jerzy, and Klukowska, Anna, Institute of Hematology and Blood Transfusion, Warsaw, Poland; Kavakli, Kaan, Ege University Hospital, Izmir, Turkey; Santagostino, Elena, and Mancuso,

Maria Elisa, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milan, Italy; DiMichele, Donna, and Giardina, Patricia, Weill Cornell Medical College, New York, USA; Rivard, Georges, Hôpital Ste-Justine, Montreal, Canada; Oldenburg, Johannes, University Clinic Bonn, Bonn, Germany; van den Berg, Marijke, and Schutgens, R., University Medical Center Utrecht, Utrecht, Netherlands; Ewing, Nadia, City of Hope National Medical CAL-101 nmr Center, Duarte, USA; Astermark, Jan, Centre for Thrombosis and Haemostasis, Lund University, Skåne University IWR 1 Hospital Malmö, Malmö, Sweden; Mäkipernaa, Anne, Clinical Research Institute Helsinki, Helsinki, Finland; Schwyzer, Rosemary, Johannesburg Hospital, Johannesburg, South Africa; Shapiro, Amy, Indiana Hemophilia and Thrombosis Center, Indianapolis, USA; Altisent, Carmen, Hospital Vall d’Hebron, Barcelona, Spain; Peréz Bianco, Raúl, Academia Nacional de Medicina, Buenos Aires, Argentina; Ducore, Jonathan, University of California, Davis, Sacramento,

USA; Leissinger, Cindy, Louisiana Comprehensive Hemophilia Care Center, Tulane University, New Orleans, USA; Ruiz-Sáez, Arlette, Centro Nacional de Hemofilia, Caracas, Venezuela; Collins, Peter, Arthur Bloom Haemophilia Center, Cardiff, Wales; Monahan, Paul, UNC Comprehensive Hemophilia Center, Chapel Hill, USA; Peters, Marjolein, Academisch Medisch Centrum, Amsterdam, The Netherlands; Valentino, Leonard, Rush University

Medical Center, Chicago, USA; Alvárez, Mayte, and Jíminez-Yuste, Victor, La Paz University Hospital, Madrid, Spain; Chalmers, Elizabeth, Royal Hospital for Sick Children, Glasgow, Scotland; Jurgutis, Romualdas, Klaipėdos 上海皓元 Jūrininkų Ligonine, Klaipėda, Lithuania; Kouides, Peter, Rochester General Hospital, Rochester, USA; Pollman, Hartmut, Hemophilia Center and Institute for Thrombosis and Hemostasis, Münster, Germany; Thornburg, Courtney, Duke University, Durham, USA; Huang, James, University of California, San Francisco, USA; Male, Christoph, Medizinische Universität Wien, Vienna, Austria; Önundarson, Páll, Landspitali University Hospital, Reykjavik, Iceland; Solano, María Helena, Hospital San Jose, Bogota, Colombia; Cnossen, M.H., Erasmus Medical Center, Rotterdam, The Netherlands; Escobar, Miguel, University of Texas Health Science Center at Houston, Houston, USA; Gomperts, Edward, Childrens Hospital Los Angeles, Los Angeles, USA; Iyer, Rathi, University of Mississippi Medical Center, Jackson, USA; Makris, Michael, Sheffield Haemophilia and Thrombosis Center, Royal Hallamshire Hospital, Sheffield, UK; Rangarajan, Savita, Guy’s and St.