The positive expression of IL-2 in colorectal cancer specimens was significantly less frequent than in border cancer specimens and the healthy tissues. This implied type 2 cytokine expression which may mediate immunosupression is predominant in colorectal LBH589 purchase cancer. Key Word(s): 1. colorectal cancer; 2. CD137; 3. IL-2; Presenting Author: AMENG SHI Additional Authors: LEI DONG,
HAITAO SHI, JIONG JIANG, XIAOYAN GUO Corresponding Author: LEI DONG Affiliations: Second Affiliate Hospital of Xian Jiao Tong University Objective: Chemokine are now known to play an important role in cancer growth and metastasis, such as the CXCL12. CXCR4 is the receptor for CXCL12 and has been found to be involved in gastric cancer. CXCR7, another receptor
for CXCL12, was recently demonstrated to have a significant impact on some tumors, but few studies have reported its association with gastric AZD2281 clinical trial cancer. The aim of this study is to investigate the expression status of CXCR7 and its clinicopathological significance in gastric cancer. Methods: Expression status of CXCR7 was detected in 35 primary gastric cancer and 35 adjacent tumor tissues by immunohistochemistry. Correlation between the expression of CXCR7 and clinicopathological factors of gastric cancer was analyzed. And the expression of CXCR7 on gastric cell line (MKN-28, BGC-823, SGC-7901, MGC-803 and HGC-27) was also detected with reverse transcription-PCR, Western bolt and immunofluorescence. Results: The expression of CXCR7 was significantly higher in gastric cancer tissues than adjacent tumor tissues (P < 0.01). However, this expression was not correlated medchemexpress with age, gender, tumor site, differential degree and helicobacter pylori infection. In addition, CXCR7 was expressed in all five kinds of cell lines with variable intensities but is most highly expressed in SGC-7901, a medium differentiated gastric adenocarcinoma cell line with high metastatic potential. Conclusion: CXCR7 was highly expressed in gastric cancer tissues and SGC-7901, which suggesting that CXCR7
may play an important role in the process of gastric cancer progression. Key Word(s): 1. CXCR7; 2. Gastric cancer; Presenting Author: JI-LIN WANG Additional Authors: YE HU, JIE XU, JING-YUAN FANG Corresponding Author: JI-LIN WANG Affiliations: Renji Hospital, Shanghai Jiao-Tong University School of Medicine; Division of Gastroenterology, Renji Hospital, Shanghai Jiao-Tong University School of Medicine Objective: Ets (E-twenty six) transcription factors play a wide range of roles in development and tumorigenesis. Elf3 (E74-like factor 3), an epithelium-specific Ets factor, has been found upregulated in breast cancer progression. However, no study was reported to examine the expression and biologic impact of Elf3 in colorectal cancer (CRC). Methods: Immunohistochemistry (IHC) was used to detect the expression of Elf3 in CRC tissues.