Patients were identified using the International Classification of Disease, Ninth Revision, Clinical Modification Elacridar concentration codes. Baseline characteristics, in-hospital complications including secondary intracerebral hemorrhage (ICH), sepsis, pneumonia, pulmonary embolism, deep venous thrombosis, urinary tract infections, and discharge outcomes (mortality, minimal disability, and moderate-to-severe

disability) were compared between the groups. Results: Of the 82,142 patients with ischemic stroke who receive thrombolytic treatment, 1072 (1.3%) was dialysis dependent. The ICH rates did not differ significantly between patients with ischemic stroke with or without dialysis who received thrombolytics (5.2% versus 6.1%).

The in-hospital mortality rate was higher in dialysis-dependent patients treated with thrombolytics (22% versus 11%, P <= .0001). After adjusting for age, sex, and comorbidities, dialysis dependence was associated with higher rates of in-hospital mortality in patients treated with thrombolytics (odds ratio, 1.92; 95% confidence interval, 1.33-2.78, P = .0005). Conclusions: The 2-fold higher odds of in-hospital mortality associated with administration of IV thrombolytics in dialysis-dependent patients who present with acute ischemic stroke warrant a careful assessment of risk-benefit ratio in this population.”
“In search of immunomodulatory selleck constituents from the Eastern Nigeria mistletoe, Loranthus micranthus Linn, two new stigmastane steroids: stigmast-7,20 (21)-diene-3 beta-hydroxy-6-one (1) and 3 beta-hydroxy-stigmast-23-ene (2); three (two new and one known) lupeol-based triterpenoid esters: 7 beta, Birinapant datasheet 15 alpha-dihydroxyl-lup-20(29)-ene-3 beta-palmitate (3), 7 beta, 15 alpha-dihydroxyl-lup-20(29)-ene-3 beta-stearate (4) and 7 beta, 15 alpha-dihydroxyl-lup-20(29)-ene-3 beta-eicosanoate (5)

were isolated and characterized following bioactivity-guided fractionation. The new compounds, 1, 2, 4 and 5 at concentrations of 10, 25 and 100 mu g/ml were subjected to cell proliferation and early activation marker (CD69) expression studies in C57B1/6 mice splenocytes using flow cytometry techniques against Lipopolysaccharide (LPS; 10 mu g/ml) and Concanavalin A (ConA; 2 mu g/ml) standards. The stigmastane steroids (1 and 2) at the highest concentration of 100 mu g/ml showed statistically significantly (p < 0.05) stimulatory activity on the C57B1/6 splenocytes compared to the controls with values of 46 +/- 0.76% and 43 +/- 0.46% compared to 7.69 +/- 0.41% recorded for the negative control. The novel lupeol esters, 4 and 5 at same concentration of 100 mu g/ml exhibited lower stimulations of 30 +/- 0.41% and 29 +/- 0.17% respectively compared to the controls above. The CD69 expression assay at the above doses showed that all the compounds have minimal stimulation.

(C) 2011 Wiley Periodicals, Inc. J Appl Polym Sci 120: 3109-3117, 2011″
“We report on molecular beam epitaxial growth of AlInSb/GaInSb metamorphic high-electron-mobility-transistor structures for low power, high frequency applications on 4 in. GaAs substrates. The structures consist of a Ga(0.4)In(0.6)Sb channel embedded in Al(0.4)In(0.6)Sb barrier layers which are grown on top of an insulating metamorphic buffer, which is based on the linear exchange of Ga versus In and a subsequent exchange of As versus Sb. Precise control of group V fluxes and substrate

temperature in the Al(0.4)In(0.6)As(1-x)Sb(x) buffer is essential to achieve high quality device structures. Good morphological selleck kinase inhibitor properties were achieved demonstrated by the appearance of crosshatching and root mean square roughness values of 2.0 nm. Buffer isolation is found to be > 100 k Omega/square for optimized growth conditions. Hall measurements at room temperature reveal electron densities of 2.8 x 10(12) cm(-2) in the channel at mobility values of 21.000 cm(2)/V s for single-sided

Te volume doping and 5.4 x 10(12) cm(-2) and 17.000 cm(2)/V Doramapimod s for double-sided Te delta-doping, respectively. (C) 2011 American Institute of Physics. [doi:10.1063/1.3544041]“
“How can clinical epileptologists and computational neuroscientists learn to function together within the confines of interdisciplinary teams to develop new and more effective treatment strategies for epilepsy? Here we introduce epileptologists to the way modelers think about epilepsy as a dynamic disease. Not only is there terminology to be learned, but also it is necessary to identify those areas where clinical input might be expected

to have the greatest impact. It is concluded that both groups have major roles to play in educating, evaluating, and shaping the direction of the efforts of each other. (C) 2010 Elsevier Inc. All rights reserved.”
“Two JNJ-64619178 new alternating copolymers based on dithienyl benzotriazole segment and phenylene vinyl unit were synthesized by Heck cross coupling method. The polymers exhibited broad absorption bands (from 300 nm to 752 nm for P1, and from 300 nm to 654 nm for P2) in the UV-visible region with optical bandgap ranging between 1.6 and 1.9 eV and proper electronic energy levels measured by cyclic voltammetry. The photovoltaic properties of the polymers as electron donors with 6.6-phenyl C61-butyric acid methyl ester as the electron acceptor in a bulk heterojunction structures were reported. Preliminary results showed moderate power conversion efficiency of 0.36% and 0.4%, respectively, under the illumination of AM 1.5, 100 mW/cm 2 with a device structure of ITO/PEDOT : PSS/polymer : PC(60)BM (1 : 3)/Ca/Al. Furthermore, the side chain effect on properties has also been investigated. (C) 2010 Wiley Periodicals, Inc.

The resultant fibers were characterized by means of transmission electron microscopy (TEM), differential scanning calorimetry (DSC), and thermogravimetric analysis (TGA). The morphology and thermal properties of PEO nanofibers with and without PAMAM dendrimer were compared and the effect of PAMAM

concentration on morphology and thermal properties of the resultant fibers was studied. The fibers had a size range of about 400-1300 nanometer in diameter with aureole morphology in most regions. The phase change temperature, phase transition heat, and the crystallinity of the produced composite fibers were determined by DSC analyses. TGA was also used to confirm the presence of PAMAM and to determine Procaspase activation the amount of it within the fibers. (C) 2009 Wiley Periodicals, Inc. J Appl Polym Sci 113: 3005-3011, 2009″
“Acanthopanax species (Araliaceae) are used in traditional medicines in Eastern cultures. In vitro and in vivo experimental selleck chemicals studies have demonstrated that many Acanthopanax species exhibit multiple biological effects against oxidative stress, inflammation, cancer, and obesity. Additionally, analytical studies have identified compounds from Acanthopanax and described their biological mechanisms of action. One

of such active compounds suppresses extracellular signal regulated kinase 1/2 phosphorylation and its kinase activity through direct binding. This compound also suppresses the activities of activator protein-1 and nuclear factor kappa-light-chain-enhancer of B cells in vitro and in vivo. Thus, further studies of the use of compounds from Acanthopanax species and more details of their mechanisms of action may help in broadening the use of Acanthopanax species in AZD6094 functional foods and pharmacological agents.”
“The

incidence of varicella zoster in adults is increasing, and may be associated with a number of significant complications. An adult male presented with varicella zoster complicated by pneumonitis and thrombosis, leading to a below-kneeamputation. Thrombosis with varicella zoster has been associated with vasculitis and free protein S deficiency. Other microthrombotic complications, such as purpura fulminans, are more common in children. Current treatment recommendations include acetaminophen (paracetamol) and lotions for symptomatic treatment. Intravenous acyclovir is recommended in the treatment of complicated varicella zoster, although it has not been shown to reduce the incidence of complications. (C) 2009 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.”
“In this work, the properties of Poly(methyl methacrylate) (PMMA)-clay nanocomposites prepared by three different manufacturing techniques viz., solution mixing, melt mixing, and in-situ bulk polymerization in presence of clay were studied.

It is shown that the optimal ratio between the outer and inner radius of the Halbach cylinder does not depend on the length of the sample volume. Finally, the efficiency of

a finite length Halbach cylinder is considered and compared with the case of a cylinder of infinite length. The most efficient dimensions for a Halbach cylinder are found and it is shown that the efficiency increases slowly with the length of the cylinder. (C) 2011 American Institute of Physics. [doi:10.1063/1.3525646]“
“Reflective surgical practice is invaluable for surgeons at all levels of experience. For trainees in particular, every surgical opportunity must be optimized for its learning potential Recording and reviewing cataract surgery is an invaluable tool We describe a video recording device that has the advantages

Semaxanib inhibitor of ease of use; low cost, portability; and ease of review, editing, and dissemination, all of which encourage regular use and reflective surgical practice”
“but the fundamental understanding of the nature of fluid flow and mixing in static mixers, is however poor. Droplet size is a very important parameter in miniemulsion systems and affects strongly the mechanism of particle formation in polymerization reactions. In this study, static mixer was used as homogenization device for emulsification of methyl methacrylate (MMA). Re number (Re) was obtained for SM inserted tube in different flow rates. It was demonstrated the nature of fluid

PLK inhibitor flow was turbulent under our experimental conditions. The relationship between droplet size-the most important variable in our study-and Weber number (We) was investigated. The results showed that the ratio of the droplet size to the pipe diameter was fit as an exponential SU5402 function with an order of -0.35. The polymerization of created droplets under certain We values by SM showed that it is possible to obtain a reasonable 1 : 1 copy of droplets to the particles. All these, indicate that using relationship between We and droplet size allow one to obtain acceptable condition of droplet nucleation in miniemulsion polymerization. (C) 2010 Wiley Periodicals, Inc. J Appl Polym Sci 120: 1591 1596, 2011″
“We report the characterization of dark line resonances observed in Cs vapor microcells filled with a unique neon (Ne) buffer gas. The impact on the coherent population trapping (CPT) resonance of some critical external parameters such as laser intensity, cell temperature, and microwave power is studied. We show the suppression of the first-order light shift by proper choice of the microwave power. The temperature dependence of the Cs ground state hyperfine resonance frequency is shown to be canceled in the 77-80 degrees C range for various Ne buffer gas pressures. The necessity to adjust the Ne buffer gas pressure or the cell dimensions to optimize the CPT signal height at the frequency inversion temperature is pointed out.

In the absence of these mechanisms, excessive shortening of telomeres reach its critical level. Excessively shortened telomeres do not protect chromosome ends, the cell division cycle is stopped while the inactivity of replication process generates cellular senescence and cell death. On the other hand, critically shortened

telomeres may promote chromosomal instability. These changes can lead to the development of carcinogenesis. In this process enzymatic activity of telomerase is reactivated. To maintain the protection of the chromosome ends, telomeres bind the stabilizing protein complex (shelterin). The presence of these protective proteins prevents undesirable DNA damage and initiates the repair system pathways. Molecular technologies enable the evaluation of telomere lengths, the analysis Givinostat in vitro of telomerase expression

and activity, and detection of mutations, polymorphic and epigenetic changes in telomere -shelterin – telomerase complex AZD9291 concentration related genes. The purpose of research is to describe new mechanisms that affect the biology of telomere lengths, and to determine the impact on bone marrow failures, development of haematological malignancies, neurodegenerative diseases and others disorders associated with chromosomal instability. The model of modern therapies based on telomere biology explains the significance of the maintenance of telomere lengths in the process of cellular senescence and carcinogenesis.”
“Functional beta-catenin phosphorylation disability is common in older adults. It is often episodic and is associated with a high risk of subsequent health decline. The severity of disability is determined by physical impairments caused by underlying medical conditions, and by external factors such as social support, financial support, and the environment. When multiple health conditions are present, they

often result in greater disability than expected because the patient’s ability to compensate for one problem may be affected by comorbid conditions. Evaluation of functional disability is most effective when the physician determines the course of the disability, associated symptoms, effects on specific activities, and coping mechanisms the patient uses to compensate for the functional problem. Underlying health conditions, impairments, and contextual factors (e.g., finances, social support) should be identified using validated screening tools. Interventions should focus on increasing the patient’s capacity to cope with task demands and reducing the demands of the task itself. Interventions for functional decline in older adults are almost always multifactorial because they must address multiple conditions, impairments, and contextual factors. (Copyright (C) 2013 American Academy of Family Physicians.)”
“There is an acute shortage of donated oocytes in the UK and clinics are largely relying on shared donation. Shared donation of oocytes is not without its ethical and moral concerns.

It may be secondary to ototoxicity, central nervous system tumors, Meniere’s syndrome, infections, or trauma or may be idiopathic.

Objective: To describe the temporal bone histopathology in one individual with idiopathic Dandy’s syndrome.

Materials and Methods: Temporal bones from 1 individual were removed at autopsy and studied using light and Nomarski microscopy.

Results: In this case, the otopathology

demonstrated vestibular atelectasis of the membranous labyrinth of the superior, lateral, and posterior semicircular canals but not the utricle or saccule bilaterally. The findings also included mild hair cell loss in the cristae of all semicircular canals and of the utricular and saccular maculae and severely reduced neuronal selleck products count in Scarpa’s ganglion bilaterally. There was also a scattered loss of inner

and outer hair cells throughout the cochlea and GS-4997 solubility dmso moderate-to-severe loss of cochlear neurons bilaterally.

Conclusion: We have reported the histopathologic findings in a case of idiopathic Dandy’s syndrome. Both temporal bones showed vestibular atelectasis of all three semicircular canals, preservation of normal saccule and utricle, and severe reduction of the neuronal population in Scarpa’s ganglion bilaterally. Both ears also showed substantial degeneration of the spiral ganglion of the cochleas. Severe Scarpa’s ganglion degeneration was also noted in the only other case of idiopathic Dandy’s Syndrome in the literature. However, that other case had no evidence of vestibular atelectasis and had normal hearing.”
“Objective: Although the majority of the adenosine triphosphate (ATP) in chondrocytes is made learn more by glycolysis rather than by oxidative phosphorylation in mitochondria there is evidence to suggest that reactive oxygen species produced by mitochondrial electron transport (ET) help to maintain

cellular redox balance in favor of glycolysis. The objective of this study was to test this hypothesis by determining if rotenone, which inhibits ET and blocks oxidant production inhibits glycolytic ATP synthesis.

Design: Bovine osteochondral explants were treated with rotenone, an ET inhibitor; or oligomycin an ATP synthase inhibitor; or 2-fluoro-2-deoxy-D-glucose, a glycolysis inhibiter; or peroxide, an exogenous oxidant; or mitoquinone (MitoQ), a mitochondria-targeted anti-oxidant. Cartilage extracts were assayed for ATP, nicotine adenine dinucleotide (NAD+/H), and culture medium was assayed for pyruvate and lactate after 24 h of treatment. Imaging studies were used to measure superoxide production in cartilage.

Results: Rotenone and 2-FG caused a significant decline in cartilage ATP (P < 0.001). In contrast, ATP levels were not affected by oligomycin. Peroxide treatment blocked rotenone effects on ATP, while treatment with MitoQ significantly suppressed ATP levels. Rotenone and 2-FG caused a significant decline in pyruvate, but not in lactate production.

5%) children, and was more common in those with EAs than in those without. The group with ADHD and EAs had a larger proportion of girls and the ADHD inattentive subtype, independent of a history of epilepsy. Future research should Baf-A1 focus on the clinical consequences of EAs in children with ADHD. (C) 2010 Elsevier Inc. All rights reserved.”
“Within the framework of a grand partition function approach, we develop a four-state model for the analysis of occupancy for dislocation defects within uncompensated n-type wurtzite gallium nitride

and compare the obtained results with those determined using the energy minimization and free energy minimization approaches of Read Selleckchem GSK-3 inhibitor [W. T. Read, Jr., Philos. Mag. 45, 775 (1954)]. The advantages of this particular formulation are its simplicity, the fact that we can now consider both p-type and n-type materials, and the fact

that it allows for the consideration of more complex core structures. The sensitivity of the results to variations in the electron-electron interactions within a given dangling bond are considered and found to be relatively minor for the case of n-type doping. (C) 2011 American Institute of Physics. [doi: 10.1063/1.3583548]“
“Background: Urodynamic testing is often regarded as essential to the proper diagnosis of bladder storage and emptying disorders but urodynamic testing is an invasive and expensive procedure. Pakistan is a developing AR-13324 molecular weight country with limited provision of urogynecological services, and therefore few urodynamic

studies. Study Design: This cross-sectional study was conducted from January 2009 to January 2010 at the Aga Khan University Hospital to assess the frequency of agreement between clinical findings and urodynamic studies in accurately diagnosing urinary incontinence. Methods: We included 157 women and their symptoms of urge urinary incontinence (UUI), stress urinary incontinence (SUI) or mixed urinary incontinence were matched with urodynamic study findings. Results: Out of 157 women 47 (29.9%) presented with SUI and 33 (21%) with UUI but urodynamic stress incontinence (USI) was found in 59 (37.6%) and detrusor overactivity in 38 (24.2%). This shows a reliability level of kappa = 0.41 for SUI and kappa = 0.7 for UUI. There was a weak agreement (kappa = 0.33) between clinical findings of urinary incontinence and urodynamic studies; in 78 cases (49.7%) the urodynamic findings matched the clinical findings. Conclusions:The poor level of agreement between clinical findings and urodynamic study interpretations re-emphasizes the fact that the bladder is not a reliable source of identifying urinary symptoms in women. Copyright (C) 2011 S.

Based on its infrared

(IR) and (1)H nuclear magnetic resonance (NMR) spectra, the product was characterized as a tetrahydrofuran (THF)-acetate derivative (2). The highest conversion efficiencies of 57 and 60% were obtained when 8-9-day-old cell suspensions of G. glabra and L. officinalis were respectively fed with 4-7 mg of compound 1 in 40 ml of medium per culture and the cells were harvested after 2-5 days of incubation. The addition of compound 1 at the beginning of the culture cycle caused severe growth depression in a dose-dependent manner, resulting in poor bioconversion efficiency of similar to 25% at 2-5 mg/culture dose only.”
“How polytopic plasma membrane (PM) proteins reach their destination in plant cells remains see more elusive. Using transgenic tobacco BY-2 cells, we previously showed that the rice secretory carrier membrane protein 1 (SCAMP1), an integral membrane protein with four transmembrane domains (TMDs), is localized to the PM and trans-Golgi network (TGN). Here, we study the transport pathway and sorting signals of SCAMP1 by following its transient expression in tobacco BY-2 protoplasts and show that SCAMP1 reaches

the PM via an endoplasmic reticulum (ER)-Golgi-TGN-PM pathway. Loss-of-function and gain-of-function analysis of various green fluorescent protein (GFP) fusions with SCAMP1 mutations further demonstrates that: (i) the cytosolic N-terminus MAPK inhibitor of SCAMP1 contains an ER export signal; (ii) the transmembrane domain 2 (TMD2) and TMD3 of SCAMP1 are essential for 8-Bromo-cAMP Golgi export; (iii) SCAMP1 TMD1 is essential for TGN-to-PM targeting; (iv) the predicted topology of SCAMP1 and its various

mutants remain identical as demonstrated by protease protection assay. Therefore, both the cytosolic N-terminus and TMD sequences of SCAMP1 play integral roles in mediating its transport to the PM via an ER-Golgi-TGN pathway.”
“Eugenia jambolana and Aegle marmelos are used extensively in the indigenous system of medicine as an anti-diabetic agent. The current investigation focuses on the serum insulin augmentation, anti-hyperglycemic and anti-hyperlipidemic property of a combined aqueous extracts of E. jambolana and A. marmelos (EA) on alloxan induced diabetic rats. The diabetes induced animals were fed with plant extracts at the increasing dosage of 200, 300 and 400 mg of body wt. The combined plant extracts administrated animals revealed a significant (P < 0.001) increment of serum insulin levels, higher reduction in hyperglycemia and hyperlipidemia when compared to the diabetic control rats (P < 0.001). The histological studies of the endocrine region of pancreas of diabetic animals revealed that shrinkage of beta cells of islets of langerhans. The combined plant extracts treated animals revealed restoration of beta-cells. The restoration of beta cells was evident at higher dose level that is, 400 mg/by wt extracts fed groups.

9 to 111.1 ml/min/1.73m(2), depending on the formula. The biggest difference between the obtained values was 29% (Grubb vs. Hoek p<0.01). After calculation of eGFR from creatinine concentration (MDRD), 7 patients were qualified to the 2nd and 3rd stage of chronic renal disease, while application of Hoek’s formula, based on cystatin C concentration, allotted 27 patients to

2nd and 3rd stage of chronic renal disease. Le Bricon formula gave eGFR values, that correlated best with albuminuria.

Conclusion: eGFR calculated using Le Bricon formula based on the cystatin C concentration was significantly lower than eGFR calculated from creatinine concentration and was more closely associated with albuminuria. Relying only on creatinine concentration eFT508 to estimate glomerular filtration rate can lead to underestimation of renal malfunction in obese patients.”
“The mechanism of the giant unipolar strain recently observed in a lead-free piezoceramic, 0.92(Bi0.5Na0.5)TiO3-0.06BaTiO(3)-0.02(K0.5Na0.5)NbO3 [S.-T. Zhang, A. B. Kounga, E. Aulbach, H. Ehrenberg, and J. Rodel, Appl. Phys. Lett. 91, 112906 (2007) was investigated. The validity of the previously proposed mechanism that the high strain comes both from a significant volume change during the field-induced phase transition, from an antiferroelectric to a ferroelectric

phase and Tyrosine Kinase Inhibitor Library purchase the domain contribution from the induced ferroelectric phase was examined. Monitoring the volume changes from the simultaneously measured longitudinal and transverse strains on disk-shaped samples showed that the phase transition in this specific material does not involve any notable volume change, which indicates that there is little contribution from a volume change due to the phase transition to the total strain response. Temperature dependent hysteresis measurements on unpoled samples of a nearby ferroelectric composition, 0.93(Bi0.5Na0.5)TiO3-0.06BaTiO(3) -0.01(K0.5Na0.5)NbO3 demonstrated

that the origin of the large strain is due to the presence of a nonpolar phase that brings the system LY411575 datasheet back to its unpoled state once the applied electric field is removed, which leads to a large unipolar strain. (C) 2009 American Institute of Physics. [DOI: 10.1063/1.3121203]“
“Purpose: Cardiovascular disease (CVD) is a major cause of death among chronic hemodialysis (HD) patients. Gender and age belong to its classical risk factors. OPG/RANK/sRANKL (Osteoprotegerin/Receptor Activator of Nuclear Factor kappa B/soluble Receptor Activator of Nuclear Factor kappa B Ligand) axis constitute a system connecting bone and vascular remodeling.

Methods: We aimed to evaluate the plasma levels of OPG, sRANKL and OPG/sRANKL ratio in 21 HD patients and 16 healthy volunteers in relation to gender, age and the other clinical parameters.

Results: OPG and OPG/sRANKL ratio were significantly higher in HD patients than in controls whereas sRANKL was similar in both groups.

In this study, variations in the thermal diffusivity of PI-clay nanocomposite films prepared by different methods were investigated. The thermal diffusivity of PI-clay nanocomposite film increased at low clay content only when unmodified clay was used, where the clay morphology was a layered structure dispersed on a nanometer scale. Moreover, the thermal diffusivity could be enhanced by controlling the tensile stress induced by spontaneous shrinkage of the film during thermal imidization. These results demonstrated that the thermal diffusivity of PI-clay

nanocomposite films is significantly affected by the dispersion and/or arrangement states of the clay. (C) 2010 Wiley Periodicals, Inc. J Appl Polym Sci 119: 3010-3018, 2011″
“In host www.selleckchem.com/products/midostaurin-pkc412.html and cancer tissues, drug metabolism and susceptibility to drugs vary in a circadian (24 h) manner. In particular, the efficacy of a cell cycle specific (CCS) cytotoxic agent is affected by the daily modulation

of cell cycle activity in the target tissues. Anti-cancer chronotherapy, in which treatments are administered at a particular time each day, aims at exploiting these biological rhythms to reduce toxicity and improve efficacy of the treatment. The circadian status, which is the timing of physiological and behavioral activity relative to daily environmental cues, largely determines the best timing of treatments. However, the influence of variations FDA-approved Drug Library research buy in tumor kinetics has not been considered AG-881 purchase in determining appropriate treatment schedules. We used a simple model for cell populations under chronomodulated treatment to identify which biological parameters are important for the successful design of a chronotherapy strategy. We show that the duration of the phase of the cell cycle targeted by the treatment and the cell proliferation rate are crucial in determining the best times to administer CCS drugs. Thus, optimal treatment times depend not only on the circadian status of the patient but also on the cell cycle kinetics of the tumor. Then, we developed a theoretical analysis of treatment outcome (TATO) to relate the circadian status and

cell cycle kinetic parameters to the treatment outcomes. We show that the best and the worst CCS drug administration schedules are those with 24 h intervals, implying that 24 h chronomodulated treatments can be ineffective or even harmful if administered at wrong circadian times. We show that for certain tumors, administration times at intervals different from 24 h may reduce these risks without compromising overall efficacy.”
“Objectives

This study investigates opioid maintenance treatment (OMT) patients found to have corrected QT (QTc) interval above 500 ms, with particular focus on past medical history, genetic testing and cardiac investigations.

Methods

Detailed medical and cardiac history was obtained, with particular focus upon risk factors.