Expression analysis of LOX2, 3, 4, 5 and DOX genes in resistant and susceptible genotypes of castor at 0 days after infection (DAI), 5 DAI and 10 DAI (30 days after sowing) was carried out using quantitative real time (RT)-PCR during castor bean-Fusarium oxysporium f. sp. ricini interaction. Results suggest that 2 (LOX2 and LOX5) of 6 Rc-LOX genes were detectable. Resistant genotypes (48-1 and SKP-84) exhibited appreciably higher expression of LOX5 during castor bean-F. oxysporium interaction, which further suggest the participation of JAK inhibitor Rc-LOX5, a type-1 LOX predicted to be 9-LOX, in wilt resistance.

(C) 2012 Elsevier B.V. All rights reserved.”
“Introduction: Similarities between pigs and humans support the relevance of Gottingen minipigs for regulatory safety pharmacology. The minipig is the species of choice for cardiovascular safety pharmacology when pivotal repeat toxicology studies are conducted in this species. Methods: 4 male Gottingen minipigs with cardiovascular telemetry transmitters received intravenous saline, esmolol (0.5, 1, 2, 4 and 8 mg/kg), medetomidine (0.04 mg/kg), remifentanil (0.5, 1, 2, 4, 8 and 16 mu g/kg) and dopamine see more (2, 8, 10, 20, 30 and 50 mu g/kg/min) and oral sotalol, (3 and 10 mg/kg). Respiratory monitoring

was conducted in 3 male and 3 female Gottingen minipigs receiving intravenous saline and methacholine (0, 3.4, 13.5 and 68 mu g/kg). Results: Heart rate (HR) corrected QT was optimal with a method based on analysis of covariance (QTca) followed by Fridericia’s standard formula. Esmolol induced a decrease in HR. Medetomidine was associated with an initial hypertension with bradycardia followed by sustained hypotension, bradycadia and prolonged QTc. Remifentanil induced a dose-dependent QTc shortening with an increase in arterial pressures.

Sotalol caused a decrease in HR and systolic arterial pressure with an increase in PR and QTc intervals. Dopamine this website induced an increase in arterial and pulse pressures. Methacholine increased tidal volume, respiratory rate and minute volume. Discussion: The results suggest that the minipig is a valid alternative to other non-rodent species for cardiovascular and respiratory safety pharmacology studies when this species is justified. (C) 2011 Elsevier Inc. All rights reserved.”
“Today, there is a strong increase in video-assisted thoracic surgery; however, there are still some diseases and interventions that need a wide pleural cavity exposure (i.e. sulcus tumours and extended resections). These complex procedures are usually performed via a standard posterolateral thoracotomy, which is a good approach but has significant disadvantage due to pain and difficulty coughing. We propose a new thoracotomy that avoids a dorsal muscle division but has the same intrathoracic exposure as a posterolateral thoracotomy.

Patients with end-stage heart or lung disease are at increased risk for cognitive and/or behavioral problems, particularly those with CHD. Follow-up of these patients after transplant is important to determine the role that psychological functioning prior to surgery has in the longer term after surgery.”
“Introduction: This study was undertaken to develop knowledge of ultrasound characteristics of germ cell testicular neoplasms,

associate these characteristics with histopathologic tumor types, and lay a foundation for study of ultrasound findings in benign versus malignant testicular lesions. Materials and Methods: The medical records and ultrasound images of 107 patients with testicular tumor were reviewed. Demographic and clinical characteristics and ultrasound findings of patients selleck chemicals llc with seminoma were compared to those of patients with non-seminoma. Results: 55 patients had seminoma (1 bilateral) and 52 non-seminoma. Ultrasound images of seminoma were more often hypoechoic, homogeneous, and lobulated than those of non-seminoma (p < 0.001). Images of non-seminoma were more often heterogeneous and cystic (p < 0.001). There was no difference in tumor GSK923295 datasheet size, multiplicity, presence of calcium or lesion

margination. Testicular microlithiasis was more common in seminoma (p < 0.02). Conclusion: Careful analysis of ultrasound images can permit an educated assessment of testicular tumor histopathology. Copyright (c) 2012 S. Karger AG, Basel”
“Background

: HNF1A-MODY (MODY3) is a common subtype of autosomal dominant diabetes. Unlike HNF4-MODY where fetal macrosomia and early postnatal hyperinsulinemic hypoglycemia have been reported, a history of transient insulin overproduction has not been recognized in individuals with HNF1A-MODY yet.

Case report : Here, we report a 40-year-old male patient with HNF1A mutation p.Arg272His (c.815G > A) with a history of fetal macrosomia (4750 g, 59 cm) and, at least, one attack of symptomatic hypoglycemia in childhood. Diabetes was subsequently diagnosed at 19 years. The proband’s daughter who developed diabetes at 16 years carries the same mutation, but her birth weight and length were in the upper SNS-032 concentration normal range, and she never experienced hypoglycemic symptoms.

Conclusion : The observation of fetal macrosomia and hypoglycemia in childhood is suggestive of a biphasic impact of the HNF1A mutation on beta-cell function over the lifespan, leading from inappropriate insulin oversecretion to final clinical diabetes.”
“We detected significant changes in the make-up of the donor pool over the past decade. That the changes in diagnosis over time did not differ between DCD and DBD groups suggests this difference is not responsible for the increase in DCD rates. Instead, we suggest that changes in clinical practice, especially in management of patients with severe brain injury may account for the increased proportion of DCD.

We compare the unfolded site frequency spectra in each to those simulated using a diffusion approximation method and build a best-fitting model of past demography. This implies an earlier, possibly glaciation-induced population bottleneck in B. taurus ancestry with a later, possibly domestication- associated Idasanutlin mw demographic constriction in B. indicus. Strikingly, the modelled indicine history also requires a majority secondary admixture from the South Asian aurochs, indicating a complex, more diffuse domestication process. This perhaps involved multiple domestications and/or introgression from wild oxen to domestic herds; the latter is plausible from archaeological

evidence of contemporaneous wild and domestic remains across different regions of South Asia.”
“A new method of preparation of poly(alkylene H-phosphonate)s by ring-opening bulk polymerization of the five- and six-membered cyclic phosphonates monomers using the nontoxic Maghnite-H(+) as the

initiator is described. Cyclic phosphonate monomers have been first synthesized. In particular, a new one-step synthesis of 2-hydro-2-oxo-1,3,2-dioxaphospholane is reported with a yield of 70%. The efficiency of the montmorillonite sheet silicate clay which exchanged with protons, called Maghnite-H(+), https://www.selleckchem.com/products/rg-7112.html as cationic initiator has been proved and the resulting biomimetic poly(alkylene H-phosphonate) s have been characterized. The Maghnite-H(+) regenerated after one turn-over has showed to be still efficient as initiator for the

ring-opening polymerization. (C) 2011 Wiley Periodicals, Inc. J Appl Polym Sci 122: 891-897, 2011″
“We have newly synthesized the alpha-Mn structured Mn3Ge thin films on GaAs(001) substrate. The single phase Mn3Ge film was grown at a growth temperature of 150 degrees C, while the secondary phase was observed above a growth temperature of 250 degrees C. The Mn3Ge films exhibited ferrimagnetism with a Curie temperature of 334 K. The saturation magnetizations were 255.9 and 313.8 emu/cm(3) and the corresponding coercive fields were 453 and 1166 Oe at 10 K for the samples RSL3 datasheet grown at 150 and 300 degrees C, respectively. The ferrimagnetism was confirmed by the anomalous Hall effect data. (C) 2011 American Institute of Physics. [doi:10.1063/1.3543777]“
“Artificial selection and experimental evolution document natural selection under controlled conditions. Collectively, these techniques are continuing to provide fresh and important insights into the genetic basis of evolutionary change, and are now being employed to investigate mating behaviour. Here, we focus on how selection techniques can reveal the genetic basis of post-mating adaptations to sexual selection and sexual conflict.

It is therefore proposed that a cesium oxide (Cs(x)O(y)) surface coating is responsible, at least in part, for the low turn E-field and superior emission characteristics of this type of fiber cathode. This Cs(x)O(y) layer could be formed during preconditioning

heating. Cs(x)O(y) surface layers cannot only lower the fiber work function by the formation of surface dipoles (if they are thin enough) but may also enhance surface emission through their ability to emit secondary electrons due to a process of grazing electron impact. These multiple electron emission processes may explain the reported 10-100 fold reduction in the turn-on E-field of coated C fibers.”
“New photoactive selleck chemicals composite based on ethyl KU-57788 concentration vinyl acetate (EVA) and SrAl2O4:Eu,Dy or Sr4Al14O25:Eu,Dy were prepared by melt mixing or extrusion methodologies. The phosphorescent behavior and material properties of

the polymer-phosphor composites were studied. The morphology of the polymer and the composites were studied by using scanning electron microscopy (SEM), transmission electron microscopy (TEM), and energy dispersive X-ray spectroscopy (EDS). The SEM. shows that the physical and chemical behavior of the matrix and the extrusion conditions were primarily responsible for the surface morphology. TEM and EDS show that the phosphor particles were uniformly dispersed in the EVA matrix. A broad band of ultraviolet (UV)-excited phosphorescence of SrAl2O4:Eu,Dy and Sr4Al14O25:Eu,Dy phosphors and the respective composites were observed at wavelengths of 516 nm and 490 nm, respectively. The photoluminescence (PL) spectra showed less intense

phosphorescence but no shift in the wavelength of the emission BI6727 peak for all the composites. The Hamburg wheel test was done on all the composites and the PL measurements before and after the test showed almost no change in the intensity of the emission. Thermal studies showed that the presence of the phosphors in the matrix slightly increased the crystallinity of EVA, which leads to higher melting enthalpies. Tensile testing shows very little change in the tensile strength and flexibility of the ethylene vinyl acetate copolymer. (C) 2009 Wiley Periodicals, Inc. J Appl Polym Sci 115: 579-587, 2010″
“Objective This study aims to test two telephone-delivered interventions for their efficacy in improving quality of life (QOL) (psychological, physical, social, and spiritual) among Latinas with breast cancer and their family members or friends (labeled supportive partners in this study). Methods Latinas with breast cancer and their supportive partners (SPs) were randomly assigned to one of two telephone delivered 8-week interventions: (i) telephone interpersonal counseling (TIP-C) or (ii) telephone health education (THE).

(C) 2013 Elsevier Ireland Ltd. All rights

reserved.”
“Chronic kidney disease (CKD) is highly prevalent in Taiwan and an increasing number of patients are affected, with a high risk of progression to end-stage renal disease and huge medical expenses. It has been predicted that the presence of hypertension increases with decreasing renal function C59 wnt due to a decrease in sodium excretion and activation of the renin-angiotensin system (RAS). The aim of this study was to investigate the influence of genetic variants of the RAS gene on CKD.

We performed a case control association study and genotyped 135 CKD patients and 270 healthy controls among Han Chinese in Taiwan. All subjects were genotyped for angiotensinogen (AGT-M235T, T174M, A-20C), angiotensin-I converting enzyme (ACE-A2350G) and angiotensin II type 1 receptor (AGTR1-A1166C, C573T, C-521T) polymorphisms of RAS genes by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. Significant associations were observed in ACE-A2350G and AGTR1-C573T polymorphism between CKD patients and controls. In regard to ACE-A2350G, compared with the AA genotype the GG genotype protected against CKD (adjusted odds ratio [OR] = 0.34; p = 0.01). In regard to AGTR1-C573T, the CT genotype was a risk for CKD compared with the CC genotype (adjusted OR = 1.82; p = 0.03). We conclude that ACE-A2350G and AGTR1-C573T

polymorphisms see more are likely candidate determinants of CKD.”
“Objective: The Revised-Illness Perception Questionnaire (IPQ-R) assesses illness perceptions according to Leventhal’s self-regulatory model. The aim of this paper is to present findings on the reliability and validity of the IPQ-R in a population of Greek cancer patients.

Methods: A total of 206 patients completed a Greek translation of the IPQ-R and the Greek version of the Beck Depression Inventory (BDI). The scale’s reliability was investigated by examining its internal consistency (Cronbach’s alpha) and its test-retest reliability. Structural validity was examined through factor analyses. Predictive validity was tested

by regressing BDI scores on IPQ subscale scores. Inter-relationships between IPQ-R dimensions were Sonidegib solubility dmso also examined by computing Pearson’s Correlation Coefficients.

Results: Cronbach’s alpha showed satisfactory internal consistency for the IPQ-R subscales. Paired samples’ t-test showed good test-retest reliability. Factor analysis of the IPQ-R items revealed that the Greek version reflects the structure of the original with the only difference being that the ‘Consequences’ and ‘Emotional Representations’ subscales loaded on one factor. Factor analysis of the causal dimension items revealed a different structure of Causal Representations than that of the original questionnaire yielding three main factors: Psychological Attributions, Behavioral, and External Factors.

Methods A total of 5,322 adolescents completed the TQOLQA, MASC-T, and the questionnaire for

socio-demographic characteristics without omission. The associations of the QOL on the TQOLQA Lapatinib ic50 with the severity of anxiety symptoms on the total MASC-T and socio-demographic characteristics were examined using multiple regression analysis. The moderating effects of socio-demographic characteristics on the association between QOL and anxiety symptoms were also examined.

Results After controlling for the effects of socio-demographic characteristics, more severe anxiety symptoms on the total MASC-T were significantly associated with poorer QOL in all seven domains of QOL on the TQOLQA. Meanwhile, socio-demographic characteristics had moderating effects on the associations between some domains

of QOL and anxiety symptoms.

Conclusions Anxiety symptoms require intervention when developing strategies to improve the QOL of adolescents. Meanwhile, clinicians should take socio-demographic characteristics into consideration when working on QOL issues and anxiety symptoms in adolescents.”
“A strain k center dot p model is used to investigate lattice temperature dependence of the piezoresistivity of p-doped silicon nanobeams in the range of 100-600 K, based on the self-consistent solution to the coupled Schroumldinger-Poisson equations. According to quasiharmonic approximation, an analytical semicontinuum atomistic lattice model buy Nec-1s is presented to describe

the effect of size and temperature on elastic constants of the silicon nanobeam by using the anharmonic Keating model. The result presented here indicates the piezoresistive coefficient of the silicon nanobeam, which is dependent Torin 2 mw on quantum confinement effects, has a negative and nonlinear temperature coefficient. A quantitative comparison of the piezoresistive coefficients calculated with and without considering the elastic constant correction shows that it is crucial to incorporate the size-dependent elastic constant correction in order to quantify the piezoresistivity.”
“Successful implantation of an embryo into the uterus requires synchrony between the blastocyst and the endometrium. Endometrial preparedness, or receptivity, occurs only for a very short time during the mid-secretory phase of the menstrual cycle in fertile women. Failure to achieve receptivity results in infertility and is a rate-limiting step for IVF success. Frozen embryo transfer in non-stimulation cycles is already improving live birth rates. However, an important tool that is missing in the armoury of reproductive specialists is a means to rapidly assess endometrial receptivity, either during initial assessment or immediately prior to embryo transfer.

These BIRB 796 solubility dmso findings suggest that C(trough) is useful for therapeutic monitoring of tacrolimus in patients receiving TAC-once. In addition, pharmacokinetics and clinical outcomes were comparable between TAC-once and TAC-twice formulations.”
“OBJECTIVE: To estimate how symptom severity, extent of bother, and quality of life differ across urinary incontinence (UI) subtypes.

METHODS: We evaluated prevalent UI cases from the Nurses’ Health Studies, including women aged 41-83 years. Women with UI (leaking more than once per month) were subclassified according to reported symptoms such as stress UI (SUI, leakage with activity),

urge UI (UUI, leakage with urgency), or mixed UI (SUI and UI co-occurring equally). The UI severity was assessed in 102,418 women based on the Sandvik severity index. In a subset of older women with weekly UI, we asked about bother (n=1,697) and quality of

life (Incontinence Impact Questionnaire; n=1,748). The UI severity, bother, and quality of life were compared across subtypes using polytomous logistic regression, adjusting for other characteristics.

RESULTS: The distributions of UI subtypes were 51% SUI, 27% UUI, and 22% mixed UI. Approximately half had slight UI, 26% had moderate UI, and 23% had severe UI. Severe UI was more common in women reporting mixed UI (37%) selleck chemicals than UUI (27%) or SUI symptoms (15%) (P<.001). More women with severe mixed (21%; P=.02) and UUI symptoms (13%; P=.1) reported being “”greatly”" bothered by their UI compared with SUI (10%). Women with severe mixed (mean

18.0; P<.001) and UUI symptoms (mean 13.4; P=.004) had higher mean incontinence effect scores compared with SUI (mean 9.8).

CONCLUSION: Women reporting mixed UI symptoms describe more severe and bothersome incontinence, with higher effect on quality of life.”
“Existing methods to determine biapenem (CAS 120410-24-4), a carbapenem, either lacked sensitivity/reproducibility or had no internal standard as a control. Here an improved reversed-phase CHIR-99021 in vitro high-performance liquid chromatographic (RP-HPLC) method was established in human plasma and urine. After adding p-aminobenzoic acid as the internal standard to plasma or urine, plasma samples were ultra-filtrated and urine samples were diluted directly. Chromatographic separations were carried out on a 4.6 mm x 150 mm column with acetonitrile-0.1 mol/l sodium acetate (2:98, v:v; pH 4.38 or 4.00) as mobile phase and UV detection at 300 nm. The extraction recovery was 91.51% for biapenem at the concentration level of 5 mu g /ml in human plasma. The linear quantification range of the method was 0.1 similar to 50 mu g /ml for plasma and urine, with linear correlation coefficients greater than 0.998. The intra-day and inter-day relative standard deviations (R.S.D.) for biapenem at low, middle and high levels in human samples were less than 12.51% for plasma and less than 7.05% for urine.

The virus presents a high degree of genetic variability owing to the combination of a lack of proofreading by the RNA-dependent RNA polymerase and a high level of viral replication. This genetic VE-822 in vivo variability allows the classification of genotypes, subtypes, isolates and quasispecies

to which epidemiological and pathogenetic significance may be associated. The features and biological implications of HCV variability and of quasispecies dynamics in infection transmission, mechanisms of chronicity and resistance to antiviral therapy are discussed.”
“Visfatin is a new adipokine involved in several processes. The data concerning visfatin in chronic hepatitis C (CHC) is small. To assess visfatin serum concentration and to study its association with biochemical

and morphological features in CHC. Seventy nonobese patients with CHC (Group 1) confirmed by the presence of serum hepatitis C virus (HCV)-RNA and 20 healthy volunteers (Group 2), similar in age and BMI with normal fasting glucose and lipid profile were included. Visfatin was significantly increased in Group 1 compared with Group 2 (55.6 +/- 23.1 vs 23.7 +/- 3.8 ng/mL; P < 0.001). Visfatin was negatively associated with necro-inflammatory activity grade (r = -0.36; P = 0.007). The lowest levels were found in patients with the most advanced inflammation: Cyclosporin A grades 3-4 – 46.8 +/- 17.1, grade 2 – 52.6 +/- 18.4 and grade 1 – 75.2 +/- 27.6 ng/mL; P = 0.017. A significant difference was also shown comparing patients with minimal inflammatory activity to the rest of the cohort (P = 0.009). Visfatin receiver operating characteristic curve analysis for different necro-inflammatory activity – grade 1 vs grades 3-4 with area under the curve 0.81 indicated a good discriminant power for differentiation of moderate/severe inflammation, with the cut-off set at 57.6 ng/mL (sensitivity 75%, specificity 90%, positive predictive value 0.90, negative predictive value 0.75). Serum visfatin concentration increases significantly in CHC patients. These findings suggest that visfatin is this website important in the pathogenesis of the inflammatory

process in CHC. Visfatin may play a dual role as a pro-inflammatory or/and protective factor. The measurement of visfatin serum concentration may serve as an additional tool in distinguishing more advanced grades of the necro-inflammatory activity.”
“Informal care provided by family and friends of patients with chronic illness, such as cancer, makes an invaluable contribution to the medical system and to society, yet it also imposes challenges that result in increased morbidity and mortality of the caregivers. Researchers studying this topic confront major difficulties in acquiring information about caregivers’ morbidity from medical records, a procedure that is costly and time consuming.

As an alternative, we developed a brief self-administered measure of morbid conditions for informal caregivers of persons with medical illness.

Certain patient and extended-catheter characteristics may contribute to loss from peritonitis.”
“Inflammatory pseudopolyps are formed in the regenerative and healing phases of ulcerated epithelium. Giant pseudopolyposis of the colon (pseudopolyp larger than 1.5 cm in size) is a very rare complication of inflammatory bowel disease and it may lead to colonic intussusception or luminal obstruction, but the more important clinical significance is that it can be endoscopically confused with a malignancy, although it is generally regarded as having no malignant potential. It has been reported that giant pseudopolyposis of the colon rarely regresses with medical management alone and this sometimes

require surgical or endoscopic resection. This report illustrates selleck chemical 2 unusual cases of giant pseudopolyps associated with Crohn’s disease and ulcerative colitis, and these giant pseudopolyps were initially confused with villous adenoma or adenocarcinoma, but they showed regression after adequate medical therapy. (C) 2011 European Crohn’s and Colitis Organisation. Published by Elsevier B.V. All rights reserved.”
“Background and Objective: The downward directed exit of the swan neck catheter may decrease the risk of exit-site infection (ESI). The percentage ARN-509 inhibitor of migrations of the swan neck catheter seems to be less than the conventional Tenckhoff catheter

and the swan neck catheter is more expensive and cannot be manipulated by guidewire technique if tip migration occurs. In this study, the conventional Tenckhoff catheter was used. The straight tunnel was converted to an arcuate one

using the triple incision method, resulting in a downward directed exit. The arcuate tunnel was created by passing the catheter through an additional incision located between the paramedian incision and the exit site. We compared the infective and mechanical complications of the Tenckhoff catheter with a downward exit, implanted using the triple incision BMS-345541 manufacturer method, with the swan neck catheter.

Patients and Methods: 101 new peritoneal dialysis patients were prospectively randomized to receive either the Tenckhoff catheter with a downward exit, implanted using the triple incision method, or the swan neck catheter. Each patient was followed up for 24 months. 50 patients were in the triple incision method group (TIMG) and 51 were in the swan neck catheter group (SNCG).

Results: Over a mean period of 18.9 +/- 8.0 months of follow-up, ESI occurred in 35 patients (70%) in TIMG and 37 patients (72.5%) in SNCG (p = 0.83). The ESI rates were 0.71 and 1.0 episodes/catheter-year in TIMG and SNCG respectively (p = 0.21). The peritonitis rates were similar in the 2 groups (0.64 episodes/year in TIMG and 0.68 episodes/year in SNCG, p = 0.47). More patients in TIMG had tip migration [15 patients (30%) in TIMG vs 10 patients (19.6%) in SNCG] but the difference was not statistically significant.

An incorrect and misleading nomenclature was responsible for clinical complications, missing denotation and even wrong treatments. These circumstances caused an urgent need for a revised revision of the nomenclature. In 2001, an international interdisciplinary committee updated and refined the nomenclature Rabusertib ic50 of the limbs. While the new nomenclature has been

accepted international in scientific studies, there are still uncertainties in clinical practice. This review refers to clinical relevant changes. A uniform and unmistakable anatomic nomenclature is the basis for a uniform language in the phlebologic fields of science and clinical practice. Misleading designations and deficits of communication put the correct diagnostics at risk and provoke mistakes of treatment.”
“Arabidopsis thaliana is a host for the sugar beet cyst nematode Heterodera schachtii. Juvenile nematodes invade the roots and induce the development

of a syncytium, which functions as a feeding site for the nematode. Here, we report on the transcriptome of syncytia induced in the roots of Arabidopsis. Microaspiration was employed to harvest pure syncytium material, which was then used to prepare RNA for hybridization to Affymetrix GeneChips. Initial data analysis showed that the gene expression in syncytia at 5 and 15 days post-infection did not differ greatly, and so both time Selleckchem 3-Methyladenine points were compared together with control roots. Out of a total of 21 138 genes, 18.4% (3893) had a higher expression level and 15.8% (3338) had check details a lower expression level in syncytia, as compared with control roots, using a multiple-testing corrected false discovery rate of below 5%. A gene ontology (GO) analysis of up- and downregulated genes showed that categories related to high metabolic activity were preferentially upregulated. A principal component analysis was applied to compare the transcriptome of syncytia with the transcriptome

of different Arabidopsis organs (obtained by the AtGenExpress project), and with specific root tissues. This analysis revealed that syncytia are transcriptionally clearly different from roots (and all other organs), as well as from other root tissues.”
“Autoimmune polyglandular syndromes are defined as a spectrum of association between 2 or more organ specific endocrinopaties and non-endocrine autoimmune diseases. Autoimmune polyglandular syndromes type 2 is characterized by the coexistence of adrenal failure with autoimmune thyroid disease and diabetes mellitus type 1. Inflammatory bowel diseases are rarely associated with these autoimmune disorders.

Here, we report about a case of 33 years old male with known history of Crohn’s colitis diagnosed in childhood. In 2003 the patient experienced sudden loss of hair, eyebrows, eyelashes, beard and body hair alopecia universalis was diagnosed.