Washington, D.C.: The National Academies Press; 2005. 11. Steele R, Wall JS, De Bodo RC, Altszuler N: Measurement

of size and turnover rate of body glucose pool by the isotope dilution method. Am J Physiol 1956, 187:15–24.PubMed 12. Wolfe RR: Isotope Tracers in Metabolic Research: Principals and Practice of Kinetic Analysis. Hoboken, NJ.: John Wiley & Sons Inc.; 2005. 13. Braun B, Mawson JT, Muza SR, Dominick SB, Brooks GA, Horning MA, Rock PB, Moore LG, Mazzeo RS, Ezeji-Okoye SC, et al.: Women at altitude: carbohydrate utilization during exercise at 4,300 m. J Appl Physiol 2000, 88:246–256.PubMed 14. Linn T, Santosa B, Gronemeyer D, Aygen S, Scholz N, Busch M, Bretzel RG: Effect of long-term dietary protein intake on glucose metabolism in humans. Diabetologia 2000, 43:1257–1265.PubMedCrossRef Olaparib in vivo 15. Millward DJ, Layman DK, Tome D, Schaafsma G: Protein quality assessment: impact of expanding understanding of protein and amino acid needs for optimal health. Am J Clin Nutr 2008, 87:1576S-1581S.PubMed 16. Jungas RL, Halperin ML, Brosnan JT: Quantitative analysis of amino acid oxidation and related gluconeogenesis in humans. Physiol Rev 1992, Selleck INCB018424 72:419–448.PubMed 17. Katz J, Tayek JA: Gluconeogenesis and the Cori cycle in 12-, 20-, and 40-h-fasted humans. Am J Physiol 1998, 275:E537-E542.PubMed 18. Krebs M, Brehm A, Krssak M, Anderwald C, Bernroider E, Nowotny P, Roth E, Chandramouli

V, Landau BR, Waldhausl W, et al.: Direct and indirect effects of amino acids on hepatic glucose metabolism in humans. Diabetologia 2003, 46:917–925.PubMedCrossRef 19. Krebs M: Amino acid-dependent modulation of glucose metabolism in humans. Eur J Clin Invest 2005, 35:351–354.PubMedCrossRef 20. Promintzer M, Krebs

M: Effects of dietary protein on glucose homeostasis. Curr Opin Clin Nutr Metab Care 2006, 9:463–468.PubMedCrossRef HSP90 21. Vogt C, Petrides AS: Stimulation of muscle glucose disposal by insulin in PI3K inhibitor humans is a function of the preexisting plasma insulin level. Am J Physiol 1995, 268:E1031-E1038.PubMed Competing interests Nancy R. Rodriguez has received honorarium for participation in the speaker bureau for the NCBA and serves on the Protein Advisory Board for the NCBA. Remaining author(s) declare that they have no competing interests. Authors’ contributions SMP participated in manuscript preparation, CSS, MAP, PCG, DRB, and BTB participated in data collection, statistical analysis, and manuscript preparation. NRR served as the principal investigator and contributed to study design, data collection, and manuscript preparation. All authors read and approved the final manuscript.”
“Background Many investigators have sought to elucidate the hormonal response to feeding, as such an understanding may provide insight into important biological processes that occur in the postprandial state. Both the meal size [1, 2] and macronutrient type [3–5] may impact the hormonal response. Although this ensuing hormonal response may be important to a variety of individuals (e.g.