Thus the AUTOPILOT-BT, has the potential to select established guidelines or to adapt the system to modified ventilation therapies. Further clinical sellckchem trials will test the actual clinical efficiency of different controllers.
Of the 14 pigs, one had to be excluded due to accidental cuff deflation. Tube sizes were evenly distributed amongst the groups. Cuff pressures were equal: TG 23.7, HL 25.2 – P < 0.2. As seen in Table Table1,1, the incidence of microaspiration was significantly less for TG in the Blue Dye and bronchitis groups.Table 1Incidence of microaspirationConclusionsThe TG provided significant microaspiration protection compared with the conventional tube in the dye and bronchitis categories. Although not statistically significant, the difference in the other two categories may be of clinical significance.

Further clinical studies are necessary to confirm this point.
Analyses of 12 patients showed that MRS reduced significantly the global amount of nonaerated tissue (54 �� 8% to 7 �� 6%, P < 0.01), tidal recruitment (4 �� 4% to 1 �� 1%, P = 0.029) (Figure (Figure1).1). Most dependent regional tidal recruitment significantly increased from PEEP 10 to 20 cmH2O (2 �� 3% to 11 �� 7%, P < 0.01), but significantly decreased after MRS (11 �� 7% to 2 �� 2%, P < 0.01). High PEEP (25 cmH2O) was necessary to sustain recruitment.Figure 1Percentage of regional (I to IV) tidal recruitment during all steps of the MRS protocol.ConclusionsMRS decreased nonaerated areas and tidal recruitment. Increasing PEEP without full recruitment may cause lung injury exacerbation in the severe ARDS population.

A total of 10,204 patients (69,913 patient-days) were included. Mean age was 59. Mean admission APACHE was 19.1. Mortality was 25%. Median ICU LOS was 4 days. A total 13.4% of the cohort (representing 9% of total patient-days) had an initial SOFA >11. Mortality in patients with an initial SOFA score >11 was 59% (95% CI 56%, 62%). Figure Figure11 demonstrates increased mortality associated with SOFA >11 during the ICU stay to a maximum of 78% (95% CI 68%, 86%) on day 14. The mortality associated with an initial SOFA >11 across diagnostic categories (ICNARC) varied from 29% for poisoning to 67% for neurological patients. Mortality associated with an initial SOFA >11 was lowest for those patients 18 to 20 years old (37%) and highest for those >80 years old (75%).

Mortality exceeded 90% when the initial SOFA was >20. However, only 0.2% of patients had an initial SOFA >20.Figure 1Hospital mortality associated with SOFA >11 during the ICU stay.ConclusionsA SOFA score >11 was not associated with a hospital mortality >90% at any time during the ICU stay. Age and diagnostic category represent potential modifying factors GSK-3 in the association of SOFA >11 and hospital mortality.