Valuable suggestions on the manuscript of Prof. Yukifumi Nawa of Faculty of Medicine, Khon Kaen University are gratefully acknowledged. References 1. Lazaridis KN, Gores GJ: Cholangiocarcinoma. Gastroenterology 2005, 128:1655–1667.PubMedCrossRef 2. Patel T: Cholangiocarcinoma. Nat Clin Pract Gastroenterol Hepatol 2006, 3:33–42.PubMedCrossRef 3. Sripa B, Pairojkul C: Cholangiocarcinoma: lessons from Thailand. Curr Opin Gastroenterol 2008, 24:349–356.PubMedCrossRef 4. Sriplung

H, Sontipong S, Martin N, Wiangnon S, Vootiprux V, Cheirsilpa A, Kanchanabat C, Khuhaprema T: STI571 purchase Cancer incidence in Thailand, 1995–1997. Asian Pac J Cancer Prev 2005, 6:276–281.PubMed 5. Kurathong S, Lerdverasirikul signaling pathway P, Wongpaitoon V, Pramoolsinsap C, Kanjanapitak A, Varavithya W, Phuapradit P, Bunyaratvej S, Upatham ES, Brockelman WY: Opisthorchis viverrini infection and cholangiocarcinoma. A prospective, case-controlled study.

Gastroenterology 1985, 89:151–156.PubMed 6. Thamavit W, Bhamarapravati N, Sahaphong S, Vajrasthira S, Angsubhakorn S: Effects of dimethylnitrosamine on induction of cholangiocarcinoma in Opisthorchis viverrini-infected Syrian golden hamsters. Cancer Res 1978, 38:4634–4639.PubMed 7. Khan SA, Thomas HC, Davidson BR, Taylor-Robinson SD: Cholangiocarcinoma. Lancet 2005, 366:1303–1314.PubMedCrossRef 8. Fodale V, Pierobon M, Liotta L, Petricoin E: Mechanism of cell adaptation: when and how do cancer cells develop chemoresistance? Cancer J 2011, 17:89–95.PubMedCrossRef 9. Logsdon CD, Simeone DM, Binkley C, Arumugam T, Greenson JK, Giordano TJ, Misek DE, Kuick R, Hanash S: Molecular profiling Entospletinib of pancreatic Baricitinib adenocarcinoma and chronic pancreatitis identifies multiple genes differentially regulated in pancreatic cancer. Cancer Res 2003, 63:2649–2657.PubMed 10. Siegel D, Ross D: Immunodetection of NAD(P)H:quinone

oxidoreductase 1 (NQO1) in human tissues. Free Radic Biol Med 2000, 29:246–253.PubMedCrossRef 11. Chao C, Zhang ZF, Berthiller J, Boffetta P, Hashibe M: NAD(P)H:quinone oxidoreductase 1 (NQO1) Pro187Ser polymorphism and the risk of lung, bladder, and colorectal cancers: a meta-analysis. Cancer Epidemiol Biomarkers Prev 2006, 15:979–987.PubMedCrossRef 12. Cullen JJ, Hinkhouse MM, Grady M, Gaut AW, Liu J, Zhang YP, Weydert CJ, Domann FE, Oberley LW: Dicumarol inhibition of NADPH: quinone oxidoreductase induces growth inhibition of pancreatic cancer via a superoxide-mediated mechanism. Cancer Res 2003, 63:5513–5520.PubMed 13. Jaiswal AK: Regulation of genes encoding NAD(P)H: quinone oxidoreductases. Free Radic Biol Med 2000, 29:254–262.PubMedCrossRef 14. Long DJ 2nd, Waikel RL, Wang XJ, Perlaky L, Roop DR, Jaiswal AK: NAD(P)H: quinone oxidoreductase 1 deficiency increases susceptibility to benzo(a)pyrene-induced mouse skin carcinogenesis. Cancer Res 2000, 60:5913–5915.PubMed 15. Ross D, Kepa JK, Winski SL, Beall HD, Anwar A, Siegel D: NAD(P)H: quinone oxidoreductase 1 (NQO1): chemoprotection, bioactivation, gene regulation and genetic polymorphisms.