These results are the first demonstration both of a pathological spatiotemporal AB in patients with right hemisphere damage and of the perceptual results of a decline find more in attention capacity

during healthy ageing. The paradigm developed here has revealed itself to be robust and adaptable to different participant groups for the exploration of interactions between spatial and temporal attentional processes. Here, we have been able to show that patients with right hemisphere damage are severely impaired at identifying letters appearing away from a central task. In fact they detect and discriminate only around 50% of these letters at both levels of central task difficulty when they appear simultaneously. This poor performance for letters appearing simultaneously with the diamond task is not simply for those on the contralesional side but also for those presented ipsilesionally (only 60% of these are detected during the high load task, see Fig. 3c). However, the critical aim of this study was to examine whether difficulties in discriminating the letters extended temporally. That is, if the peripheral letters appear after the central diamonds, is there a protracted period over which discrimination remains poor? Further, is this posited lag period affected by

the attentional demand of the central task? Our results demonstrate that, when there was a high attention demand in the central task, patients were impaired in accurately CH5424802 responding to these letters for a lag period that lasted for up to 850 msec. They failed to accurately discriminate significantly more letters at an SOA of 850 msec than when these letters were simultaneously presented with the diamonds. Critically, although patients and controls demonstrate very different performance in their perception away from fixation, performance of both groups for the central task, at both levels of attentional demand, was equivalent. Therefore, there was not a generalized loss of ability but rather specific buy 5-Fluoracil failures, revealed both spatially and temporally,

in secondary task completion when a large amount of attention was required in a central task. There is effectively less visual field available and so fewer letters are correctly identified away from fixation; we did not find a near versus far effect. The results of Experiment 1 align well with previous research on similar patients who have shown that increasing the amount of attention required in a central task increases the ipsilesional bias (e.g., Peers et al., 2006) and decreases neural activity for contralesional stimuli (e.g., Vuilleumier et al., 2008). Here we extend this to examine the temporal dynamics of these phenomena, revealing that the increased ipsilesional bias and loss of perception on the contralesional side extends forward in time. The patients tested here all had suffered from right hemisphere lesions. The majority of them had cortical damage, involving parietal cortex (4/5 patients).