The objective of the present work was to identify interactions by evaluating the originals of prescriptions archived from ward clinical of a hospital
specializing in cardiology in the city of Campina Grande/PB, Brazil. The study had transversal, retrospective, and observational character with quantitative approach, and was held in the period from June to July 2010. A total of 196 prescriptions were analyzed and of these, 89.6 % had some type of interaction, and 28.0 Apoptosis Compound Library % of prescriptions had at least one interaction. The most frequent involved were deslanosideo and furosemide (15.1 %), being classified as moderate. This study showed the importance of the pharmacist in the analysis of requirements, who may exercise the clinical pharmacy and contribute to the continuos education on medicines.”
“The Selleck GDC973 stability of corn oil-in-water emulsions coated by milk proteins, sodium caseinate (CAS), or whey protein concentrate (WPC), was compared under the environmental stress of pH change. Emulsions were prepared at 0.1 of protein:oil because the majority of droplets were relatively small (d(32)=0.34 and 0.35 mu m, d(43)=0.65 and 0.37 mu m for CAS- and WPC-emulsions, respectively) and there was no evidence of depletion flocculation. As the pH of the emulsions was gradually dropped from 7 to 3, there was no significant difference in the electrical charges of the emulsion droplets between the 2 types
of emulsions. However, laser diffraction measurements, microscopy measurements, and creaming stability test indicated that WPC-emulsions were more stable to droplet aggregation than CAS-emulsions under the same circumstance of pH change. It implies that factors other than electrostatic repulsion should contribute to the different Ion Channel Ligand Library magnitude of response to pH change.”
“The aim of the study was to formulate and
evaluate controlled release microspheres. Ciprofloxacin HCl, belonging to the class of fluroquinolones, was chosen as the model drug. The drug-loaded microspheres were prepared with different ratios of polymers like sodium alginate and sodium carboxy methyl cellulose (CMC) by w/o emulsification solvent evaporation method. The prepared microspheres were characterized by FT-IR spectroscopy, differential scanning colorimetry for drug polymer compatibility studies and scanning electron microscopy for surface morphology. The resulting microspheres were found to be small, discrete, spherical and free flowing. They were further evaluated for their micromeritic properties, particle size analysis, drug loading and entrapment efficiency. The mean particle size was 201.21 mu m. In vitro drug release studies revealed that formulation Fm6 containing sodium CMC as the polymer showed greater sustained effect for 10 hours. Stability studies showed no significant changes in the drug content and physical appearance.