Somatisation disorder is more prevalent in females (2% female compared to 0.2% male), and hence somatic symptoms in men should be further highlighted as potential underlying depression or general medical complaint.4 One of the theories surrounding somatisation disorder is that it occurs due to a heightened sensitivity to internal physical conditions. Reduced serotonin and increased cortisol found in depression Inhibitors,research,lifescience,medical will cause effects on body organs, and as such result in somatic symptoms.5 Therefore, it is possible

for somatisation disorder to in fact be physiologically linked to depression and as such should form part of the diagnostic workup. This difference in sex and suicidal ideation that Seidsafari et al.1 have highlighted warrants further investigation, Inhibitors,research,lifescience,medical namely because as the authors describe briefly, this may be due to cultural differences. Perhaps when comparing Iranian and Western cultural differences, we could determine whether Iranian culture is providing prevention of suicidal ideation to men, or increased suicidal ideation to women, compared to the Western world. Inhibitors,research,lifescience,medical The answer to this question could be of huge relevance to depression management. It would further enable treatment to focus on adjusting to a different style of living than the typical Selective Serotonin reuptake inhibitors that we prescribe to this patient set. In summary, the authors have highlighted

the importance of symptoms in depressed patients, which are sometimes overlooked. It is very easy to put these somatic symptoms down to factitious disorders, and overlook depression, but the epidemiology of such factitious disorders suggests that using this approach results in overlooking patients potentially Inhibitors,research,lifescience,medical at risk. It has also been highlighted that it is important to further analyse suicidal ideation Inhibitors,research,lifescience,medical and sex and for further comparisons to be drawn. Conflict of Interest: None declared.
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are variants of acute,

rapidly progressive mucocutaneous reactions. These reactions differ only in their body surface area (BSA) mafosfamide involvement: whereas SJS is the less severe condition insofar as skin sloughing is limited to less than 10% of the BSA, TEN involves sloughing of more than 30% of the BSA. The SJS/TEN overlap syndrome describes patients with the involvement of greater than 10%, but less than 30% of the BSA.1 TEN and SJS (TEN-SJS) is a life-threatening condition, where there is extensive detachment of the skin characterized by full-thickness necrosis of the selleckchem epidermis. Most cases of SJS-TEN are drug-induced. In patients with no drug use, TEN-SJS is induced by chemicals, Mycoplasma pneumonia, immunization, and viral infections.2,3 We describe here a patient with the SJS/TEN overlap syndrome, who developed severe interstitial pneumonia caused by a cytomegalovirus in the wake of treatment with antiepileptic drugs. Case History Miss.