Several years later, Gibbs and Lennox were the first to recommend

Several years later, Gibbs and Lennox were the first to recommend cerebral excisions in several patients with uncontrolled epilepsy based on EEG. Moving to the University of Illinois at Chicago in 1944, Gibbs founded a consultation clinic for epilepsy, performed the first EEG depth recordings using pneumoencephalography-guided stereotaxy, and noted that sleep EEGs in patients with psychomotor seizures

frequently Batimastat molecular weight disclosed temporal epileptic patterns. Gibbs convinced Percival Bailey to collaborate on patients with refractory temporal lobe psychomotor seizures without tumors. In 1947, the first nonlesional temporal lobe excisions based on EEG localization were performed in these patients, and, by 1948, anterior temporal lobectomy had become their procedure of choice. Gibbs and Lennox received the coveted Lasker Award among other honors as pioneers in establishing the modern era of epilepsy diagnosis and treatment.”
“Nontypable Haemophilus influenzae is a common cause of human disease and initiates infection by colonizing Fosbretabulin research buy the upper respiratory tract. Adherence to respiratory epithelium is an important step in the process of colonization and is influenced by adhesive proteins called adhesins. In similar to 80% of nontypable H. influenzae isolates, the major adhesins

are related proteins called HMW1 and HMW2. Here, we summarize recent advances in our understanding of HMW1 and HMW2 as prototype members of the bacterial two-partner secretion pathway and examples of the expanding number of bacterial glycoproteins, highlighting experimental approaches that might be useful

in studies of other secreted proteins and glycoproteins.”
“Long-lasting memories of adverse experiences are essential for individuals’ survival but are also involved, in the form of recurrent recollections of the traumatic experience, in the aetiology of anxiety diseases (e. g., post-traumatic stress disorder [PTSD]). Extinction-based erasure of fear memories has long been pursued as a behavioral way to treat anxiety disorders; yet, such a procedure turns out to be transient, context-dependent, and ineffective unless it is applied immediately after trauma. Recent evidence indicates that, in both rats and humans, extinction training can prevent the return of fear if administered within the reconsolidation window, when memories become temporarily labile and susceptible of being updated. Here, we show that the reconsolidation-extinction procedure fails to prevent the spontaneous recovery of a remote contextual fear memory in a mouse model of PTSD, as well as the long-lasting behavioral abnormalities induced by traumatic experience on anxiety and in both social and cognitive domains (i.e., social withdrawal and spatial learning deficits).

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