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“Paraoxonase-1
(PON1), a high-density-lipoprotein-(HDL-) associated enzyme, has the potential to protect against atherogenesis. We examine the relationships between plasma PON1 activity and the progression of atherosclerosis aswell as coronary artery disease (CAD). Fasting blood samples were collected from female apolipoprotein E-deficient (apoE(-/-)) mice and 149 patients undergoing coronary angiography for the biochemical parameters measurement. The severity of CAD was defined using angiographic Gensini score (GSS). Compared to 3-month-old apoE(-/-) mice, aged mice had significantly lower PON1 activity, which is negatively correlated with the size of atherosclerotic lesion and plasma check details interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) levels. In study patients, PON1 activity was correlated with age, sex, and HDL-cholesterol, apolipoprotein AI, and high-sensitivity C-reactive protein (hs-CRP) levels and was significantly lower in CAD group than that in non-CAD control group. Interestingly, PON1 activity in
severe CAD group (GSS > 40) was further significantly reduced compared to those in mild and moderate subgroups (GSS <= 40) (P<0.01). There buy PXD101 is a significant correlation between PON1 activity and the severity of CAD as assessed by GSS (r = 0.393, p<0.001). PON1 activity may be a potential biomarker for the severity of CAD.”
“This article contains a review of the main developments in the field of geriatric cardiology reported during 2009. The focus is on research into the specific characteristics of elderly patients with heart failure, arrhythmias or ischemic heart disease or who have undergone percutaneous intervention for aortic stenosis.”
“Zein and zein/poly-L-lactide (PLLA) nanofiber MLN4924 clinical trial yarns were prepared by Conjugate electrospinning using coupled spinnerets applied with two high electrical voltages of opposite polarities in this article. Structure and morphology of zein yarns were investigated by SEM and X-ray
diffraction. The results showed that zein yarn consisted of large quantity of fibers with diameters ranging from several hundreds nanometers to a few microns, and zein concentration played a significant role on the diameter of nanofibers in yarns. To improve mechanical property of nanofiber yarns, PLLA was then incorporated with zein. Zein/PLLA composite nanofiber yarns conjugate electrospun from solution with concentration of 7.5% (zein, w/v)/7.5% (PLLA, w/v) exhibited tensile strength of 0.305 +/- 0.014 cN/dtex. The composite yarns showed better nanofiber alignment along the longitudinal axis. (C) 2009 Wiley Periodicals, Inc. J Appl Polym Sci 114: 2079-2086, 2009″
“Introduction and objectives. Our aim was to investigate prospectively the association between two major cardiovascular risk factors: smoking and weight gain.
Methods.