Methods: Colonoscopy was performed on 50 asymptomatic FDR of CRC patients. Participants were at least 10 years younger than the index case or at least 40 years old. Those with familial CRC of the syndromic type and those with inflammatory bowel disease were excluded. Respondents were also asked to fill up a data collection sheet on possible risk factors and determinants of acceptance of screening colonoscopy. Results: A total of 38 polyps

were removed from twenty FDR. Only one polyp had a size > 10 mm. One FDR had a mass at the ascending colon, occupying 60% ZVADFMK of the lumen, while another had a mass at the descending colon, occupying 10% of the lumen. Please see Table 1 for the histopathology

LDK378 research buy reports of the biopsy specimens. The overall prevalence of advanced neoplasia in our population is 8% (4/50). Majority of the affected FDR (13/22) had lesions located primarily at the distal colon and rectum. Six respondents had synchronous lesions. The rest had lesions situated exclusively at the proximal colon. On univariate analysis, obesity (BMI > 25) was significantly associated with advanced neoplasia among FDR of CRC patients (Pearson chi2 (1) = 4.1246, p = 0.042) at 5% level of significance. Age, sex, dietary intake, physical activity, smoking history, and alcoholic intake were not significantly associated with advanced neoplasia in our setting. The top determinants for willingness to undergo colonoscopy in our target population are increased perceived risk of the disease (86%) and recommendation from a physician to be screened (60%). Conclusion: The prevalence of colorectal neoplasia in FDR of CRC patients in the Philippines is similar to that in Western countries. Obesity is a significant

risk factor for developing such lesions in our setting. Early screening and lifestyle modification in this high-risk population should be implemented. The physician plays a key role in this advocacy. Key Word(s): 1. colonoscopy; 2. colorectal cancer; MCE Table 1. Histopathology reports of colonic polyps and mass Histapathology report Frequency (n = 40) Percentage Chronic colitis 11 27.5% Hyperplastic polyp/s 14 35% Retention polyp 1 2.5% Tubular adenoma 7 17.5% Tubulovillous adenoma 2 5% Adenocarcinorna 2 5% Presenting Author: OM PARKASH Corresponding Author: OM PARKASH Affiliations: aga Khan University Karachi Objective: Colorectal Carcinoma (CRC) is the fourth most common cancer in men and the third most common cancer in women worldwide. Methods: The increased risk of thromboembolic events associated with invasive procedures, chemotherapy, immobilization and malignancy induced hypercoagulable state are well documented in Literature.