METHODS: A total of 169 hypertensive patients were eligible for this study. Patients with atrial fibrillation (n = 75) were allocated to the atrial fibrillation group, and 94 subjects without atrial fibrillation were allocated to the control group. The PCR-based restriction fragment length polymorphism technique was used to assess the genotype frequencies.
RESULTS: The distributions of the angiotensin-converting enzyme 2350 G/A genotypes (GG, GA, and AA, respectively) were 40.43%, 41.49%, and 18.08% in the controls and 18.67%, 46.67%, and 34.66% in the atrial
fibrillation subjects (p = 0.037). The frequency of the check details A allele in the atrial fibrillation group was significantly greater than in the control group (58.00% vs. 38.83%, p = 0.0007). Compared with the wild-type GG genotype, the GA and AA genotypes had an
increased risk for atrial fibrillation. Additionally, atrial fibrillation patients with the AA genotype had greater left atrial dimensions than the patients with the GG or GA genotypes (p < 0.01 and p < 0.05, respectively).
CONCLUSIONS: The results obtained in this study indicate that the angiotensin-converting enzyme 2350 G/A polymorphism is associated with atrial fibrillation and that the A allele shows an increased risk for atrial fibrillation in Han BI 2536 order Chinese patients with essential hypertension.”
“Aim of the study: To evaluate a novel esophageal heat transfer device for use in inducing, maintaining, and reversing
hypothermia. We hypothesized that this device could successfully induce, maintain (within a 1 degrees C range of goal temperature), and reverse, mild therapeutic hypothermia in a large animal model over a 30-h treatment protocol.
Methods: Five female Yorkshire swine, weighing a mean of 65 kg (range 61-70) kg each, were anesthetized with inhalational isoflurane via endotracheal intubation and instrumented. The esophageal device was connected to an external chiller and then placed into the esophagus and connected to wall suction. Reduction to goal temperature was achieved by setting the chiller to cooling mode, and a DAPT solubility dmso 24 h cooling protocol was completed before rewarming and recovering the animals. Histopathologic analysis was scheduled for 3-14 days after protocol completion.
Results: Average baseline temperature for the 5 animals was 38.6 degrees C (range 38.1-39.2 degrees C). All swine were cooled successfully, with average rate of temperature decrease of 1.3 degrees C/h (range 1.1-1.9)degrees C/h. Standard deviation from goal temperature averaged 0.2 degrees C throughout the steady-state maintenance phase, and no treatment for shivering was necessary during the protocol. Histopathology of esophageal tissue showed no adverse effects from the device.