In most observational studies patients who underwent simultaneous hepatectomy or delayed hepatectomy was decided by the surgeon, and the allocation was based on surgeon preferences according to intraoperative findings and their own experience, which tended to increase the risk of bias for the results. In addition, universal definitions Gefitinib in vitro of postoperative complications were not available among the included studies. It is common sense that the best method to establish the selection criteria would be based on the individual patient data analysis (IPD meta-analysis); however, this is not

always available, and the diverse reporting forms from the included studies could reduce the reliability of the conclusion. In summary, this systematic review and meta-analysis was conducted at an appropriate time because enough data has accumulated for inspection by meta-analytical

methods when a simultaneous resection strategy for SCRLM patients is used more commonly. From the present pooled estimates, simultaneous resection is as efficient as a delayed procedure for long-term survival. There is evidence implying that in selected SCRLM patients less than 70 years old, without severe coexistent disease and undergoing colectomy combined with minor liver resection, simultaneous resection is a safe procedure. Future RCTs are awaited to confirm this conclusion. The authors thank Prof. Yuan-Tao Hao, Department of Medical Statistics, Sun Yat-sen University, Guangdong, PI3K Inhibitor Library manufacturer China, for statistical advice; Yan Jia, Medical Library of North Campus, Sun Yat-sen University, Guangdong, China, for literature search. Author Contributions: Z.Y., C.L., Y.C., Y.B., and C.S.: data collection and elaboration, statistical analysis; Z.Y., C.L., Y.C., and R.Y.: writing of the article; D.Y. and J.W.: supervision of the study. Additional

Supporting Information may be found in the online version of this article. “
“Increased basal release of nitric oxide (NO) in the splanchnic circulation contributes to elevated plasma levels of NO observed in decompensated cirrhosis. We evaluated in rat mesenteric arteries whether the differences in basal release of NO, revealed by asymmetric dimethylarginine (ADMA)- and NG-nitro-L-arginine methyl ester (L-NAME)-induced contractions, were associated with changes in messenger RNA (mRNA) expression of endothelial NO synthase (eNOS) and dimethylarginine dimethylaminohydrolases Dichloromethane dehalogenase (DDAHs). Rat small mesenteric arteries from 14 Sham-control, from 14 with partial portal vein ligation (PPVL), and from 14 with bile duct excision (BDE)-induced cirrhosis were precontracted under isometric conditions with norepinephrine, and additional contractions were induced with ADMA and L-NAME. mRNA expression of eNOS, DDAH-1, and DDAH-2 in mesenteric arteries were evaluated by real-time polymerase chain reaction. ADMA and L-NAME caused concentration- and endothelium-dependent contractions. pD2 values to L-NAME were similar in all groups.