However, when these indices have been used to assess the ability of dietary supplements to enhance recovery after heavy eccentric
exercise, they have been unable to detect a treatment DNA Damage inhibitor effect [10, 13]. Muscle soreness, assessed by the subjective pain rating in the present study, is one of the most commonly used measures of exercise-induced muscle injury [2]. However, Warren et al. [2] suggested that soreness correlates poorly with muscle function. In the current study, the patterns of recovery for hanging joint angle, relaxed arm circumference, and subjective pain ratings were similar in the ANA and PLA conditions (Figure 3b). Therefore, the lack of effect of supplementation on the hanging joint angle and relaxed Dehydrogenase inhibitor arm circumference in these studies [10, 13], the poor correlation between muscle function and soreness [2], and the results of the present study have collectively suggested that these indicators of muscle damage may not be sensitive to dietary supplement interventions to improve recovery from eccentric-induced muscle learn more damage. Future studies may wish to consider these
findings when selecting outcome variables for assessing the efficacy of dietary supplementation for reducing muscle damage. A secondary objective of this study was to examine the effects of 10 days of ANA dietary supplementation on resting heart rate and blood pressure. As a minor alkaloid with a similar chemical structure to nicotine, we hypothesized that tuclazepam ANA would cause moderate decreases in systolic and diastolic blood pressure and small increases in resting heart rate. Previous studies [14, 26, 27] have shown that acute nicotine exposure causes an increase heart rate and blood pressure through stimulation of the sympathetic nervous system. Minami et al. [28] showed that smoking cessation caused a reduction in heart rate, which implied that chronic nicotine use may elevate heart rate. However, cross sectional studies [26,
29] have shown that systolic and diastolic blood pressures are lower in smokers than in non-smokers. The results of the present study indicated that, over a period of 10 days, ANA had no effect on heart rate or blood pressure compared to placebo. Thus, ANA supplementation may be safe regarding short-term use (10 days) on resting heart rate and blood pressure. However, future studies may wish to examine the acute and chronic effects of ANA consumption on blood pressure and heart rate to further discern its safety. Conclusions In conclusion, ANA supplementation had no effect on the recovery of muscle strength, hanging joint angle, arm swelling, or subjective pain ratings after a bout of maximal eccentric exercise in the forearm flexors. Therefore, ANA may not be beneficial for those seeking to improve recovery from heavy exercise training or competition.