Eighteen specimens were obtained at the end of the study Histomo

Eighteen specimens were obtained at the end of the study. Histomorphometric analysis was performed on 12 specimens, mechanical kinase inhibitor Calcitriol testing was applied to 6 specimens and the RFA was applied to all specimens. Resonance frequency analysis The difference between the ISQ values measured at the time of sacrification and at the time of implant placement was used for making comparison between the LIPU and control groups. Alteration of ISQ values of the LIPU sides was higher when compared to their control sides in all weeks except in two subjects, which were sacrificed in the second and sixth weeks. The ISQ values of the LIPU group were increased at the time of sacrification in all weeks except for the first week. However, decrease of the ISQ values were recorded on first and the fourth weeks in subjects in the control group.

The ISQ value alterations in the LIPU were higher than the control group both in the early and the late period of osseointegration. However, the difference was not statistically significant. The mean values of ISQ value alterations in the early and late periods were given in Table 2. Table 2 Mean normalized values of ISQ alterations (ISQ value at time of sacrification- ISQ value at the time of implantation). Mechanical test The removal torque values for the LIPU group were measured as 69.6 Ncm, 90.4 Ncm and 98.6 Ncm at 2nd, 4th and 6th weeks, respectively. The values for the control group were measured as 67.4 Ncm, 79.6 Ncm and 84.2 Ncm, respectively (Table 3). No statistical analysis was conducted on the data due to the small sample size.

Table 3 Torque removal test results of each animal (N.cm). Histomorphometry The mean values of the histomorphometry parameters of each subject were evaluated according to the sacrification period. The histomorphometry test results in the early and late period for the LIPU and control group are shown in Table 4. The mean bone-implant contact value was significantly increased in the late osseointegration period for the LIPU group compared to the control group. Both the bone volume and the bone area values in the LIPU group showed a significant increase in the early osseointegration period but not in the late osseointegration period. Other histomorphometry parameters did not show any statistically difference between the two groups neither in the early nor in the late osseointegration period (Table 4) (Figure 2).

Figure 2 The histologic sections of 2nd week LIPU (a), 2nd week control (b), 4th week LIPU (c), 4th week control (d) (Toluidine BlueX40). Note the new bone formation (black arrows) outside the original bone in Figure 2C. (OB Entinostat = original bone, NB = new bone). Table 4 Mean scores of the histomorphometry parameters for the control and LIPU groups. DISCUSSION The histomorphometry parameters that were utilized in this study showed a positive effect of LIPU application on dental implant osseointegration specifically in the early osseointegration period.

Leave a Reply

Your email address will not be published. Required fields are marked *

*

You may use these HTML tags and attributes: <a href="" title=""> <abbr title=""> <acronym title=""> <b> <blockquote cite=""> <cite> <code> <del datetime=""> <em> <i> <q cite=""> <strike> <strong>