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“Purpose: To improve the understanding of the etiological relation between type 2 diabetes and urinary incontinence, we examined associations between diabetes and urinary incontinence type in 71,650 women 37 to 79 years old in the Nurses’
Health Study and the Nurses’ Health Study II.
Materials and Methods: From 1976 to 2000 in the Nurses’ Health Study and 1989 to 2001 in the Nurses’ Health Study 11 participants reported diagnoses of type 2 diabetes. Women with incident urinary incontinence at least weekly were identified from 2000 to 2002 in the Nurses’ Health Study and 2001 to 2003 in the Nurses’ Health Study 11, We pooled data from the 2 cohorts, ML323 purchase and estimated odds ratios and 95% confidence intervals using multivariable logistic regression adjusting for age, parity, body check details mass index, smoking, hysterectomy, functional limitations, menopausal status, postmenopausal hormone use, incontinence promoting medications and study cohort.
Results: The incidence of at least weekly urinary incontinence was 5.3% (3,612 of 67,984) among women without type 2 diabetes and 8.7% (318 of 3,666) among women with diabetes. Overall the multivariable adjusted odds of incident urinary incontinence were increased 20% (OR 1.2, 95% Cl 1.0-1.3, p = 0.01) among women with vs without type 2 diabetes. This increase appeared largely explained
by significantly greater odds of urge urinary incontinence (OR 1.4, 95% CI 1.0-1.9, p = 0.03). There was no apparent association between diabetes and stress (p = 0.3) or mixed (p = 0.6) urinary incontinence, although confidence intervals were somewhat wide.
Conclusions: Our findings suggest that type 2 diabetes may especially influence urge urinary incontinence. Further research is needed to confirm this finding and identify pathways linking these conditions.”
“Purpose: We studied urodynamic characteristics and bladder sensory function in the early stages of diabetic bladder dysfunction in diabetic Erastin women.
Materials and Methods: A total of 86 consecutive type 2 diabetic women with minimal confounders of voiding dysfunction followed
at a diabetes clinic were prospectively enrolled and subjected to urodynamic studies. The sensory response of AS and C fibers of the bladder was measured by intravesical current perception threshold testing at frequencies of 250 and 5 Hz, respectively.
Results: Of these 86 women 30 (34.9%) were classified as having detrusor un-deractivity, 12 (14.0%) presented signs of detrusor overactivity, 11 (12.8%) were referred to as having bladder outlet obstruction and 33 (38.4%) showed normal detrusor function on urodynamics. The normal detrusor function group was the reference group. The detrusor underactivity group showed impaired emptying function and decreased sensation on cystometry and intravesical current perception threshold testing.