8% vs. 59.2%, P < 0.05); patients on combined consolidation therapy > 2-years with lower baseline HBV-DNA (< 105copies /mL) had a low cumulative relapse rate of 15.4%. Eight cases had HBsAg seroconversion without relapse. Baseline HBV-DNA and HBsAg at the end of treatment were two factors predictive of relapse. Conclusions: This study demonstrated that a GDC-941 50% of relapse in NUCs-naïve CHB patients under LdT and LAM treatment. Most of the relapses

occurred within 4-years. Lower relapse rate as an ideal long-term durability could be observed in patients who achieved EVS with extended consolidation therapy and had lower baseline HBV-DNA. HBsAg seroconversion was a solid indicator

for sustained viral response. Disclosures: The following people have nothing to disclose: Hong-Ying Pan, Hong-Yi Pan, Li Chen, DanHong Yang, HaiJun Huang, YongXi Tong, Cui-Rong Chen, XingJiang Jian Background/Aim : Although entecavir (ETV) has high potency for hepatitis B virus (HBV) infection, partial virological response (PVR) has been shown in some patients. There are limited data of long-term ETV therapy in PVR patients. LY294002 The aim of this study was to determine the probability of response during long-term ETV therapy in PVR patients and to analyze tenofovir diso-proxil (TDF) efficacy on these patients. Methods: We retrospectively studied 120 patients with PVR (detectable HBV DNA at 12 months of therapy) to ETV. We compared the cumulative probability of complete virological response

MCE公司 (defined as HBV DNA <20 IU/ml), HBV DNA levels, and HBe Ag loss during prolonged therapy in nucleot(s)ide analogue (NUC)- naTve patients to NUC-experienced patients. We also analyzed CVR rate in patient switched from ETV to TDF Results: Among 120 patients, 96 (80.0%) were NUC- naTve. The cumulative probability of achieving CVR was significantly high in NUC- naTve group (51.2% vs. 39.5% at 12months, 71.1% vs. 39.4% at 24months, 77.3% vs. 39.4% at 36months of treatment from the time of PVR, p=0.036). There were no differences in change of HBV DNA and HBe Ag loss rate in two groups. Upon multi-variate analysis, HBV DNA at PVR (p=0.001) and NUC- experience (p=0.013) were associated with CVR at 24months from the time of PVR. In prediction of CVR at 24month, HBV DNA ≤177 IU/ml at the time of PVR showed 76.2% of sensitivity and 81.6% of specificity (AUROC 0.804, p=0.000). In subgroup analysis in patients switched to TDF or added TDF, the cumulative probability of CVR was 93.1% at 6 months of therapy. Conclusion: TDF therapy is effective for achieving CVR in ETV PVR patients. We should consider TDF therapy in patients with PVR, if patient have NUC- experience or HBV DNA is above 177 IU/ml at the time of PVR.