35 2 mg.kg−1 nano-SiO2 12.32 ± 4.77 29.80 ± 5.00a 13.62 ± 1.82 2 mg.kg−1 SWCNTs 9.34 ± 2.40 34.21 ± 6.73a 13.66 ± 1.72 10 mg.kg−1 nano-Fe3O4 10.05 ± 1.76 40.59 ± 10.56a 13.36 ± 1.41 10 mg.kg−1 nano-SiO2 14.76 ± 4.16 33.21 ± 5.80a 17.72 ± 1.80a,b 10 mg.kg−1 SWCNTs 10.11 ± 3.07 42.92 ± 16.20a 17.08 ± 1.35a,b aCompared

with control click here group, p < 0.05. Comparative proteomic comparisons The separation of 1.5 mg of protein samples resulted in 2-D spot patterns. Approximately 850 protein spots could be visualized at a pH of 3 to 10 and Mr 14,400 to 97,000, and their normalized volumes were compared statistically. (H) Protein solutions from the lungs of male and female rats see more were separated by IEF (linear pH gradient from pH 3 to 10) and SDS-PAGE (13% polyacrylamide gel) methods, respectively . Table 5 Relative volumes of significantly altered protein spots isolated

from lung samples of rats Spot Control H-nano-SiO2 L-nano-SiO2 H-nano-Fe3O4 L-nano-Fe3O4 H-SWCNTs L-SWCNTs 1 0.103 ± 0.020 0.195 ± 0.019a 0.184 ± 0.012a 0.162 ± 0.016a 0.172 ± 0.014a 0.160 ± 0.026a 0.194 ± 0.033a 2 0.087 ± 0.020 0.024 ± 0.011a 0.012 ± 0.003a 0.027 ± 0.008a 0.039 ± 0.014a 0.020 ± 0.010a 0.026 ± 0.005a 3 0.330 ± 0.039 0.128 ± 0.021a 0.182 ± 0.030a 0.200 ± 0.038a 0.143 ± 0.016a 0.140 ± 0.015a 0.182 ± 0.059a 4 0.356 ± 0.049 0.203 ± 0.015a 0.215 ± 0.022a 0.226 ± 0.011a ioxilan 0.231 ± 0.026a 0.201 ± 0.023a 0.208 ± 0.019a 5 0.014 ± 0.006 0.032 ± 0.008a 0.030 ± 0.006a 0.031 ± 0.005a 0.032 ± 0.004a 0.040 ± 0.005a 0.031 ± 0.003a 6 0.193 ± 0.030 0.405 ± 0.047a 0.382 ± 0.045a 0.404 ± 0.044a 0.400 ± 0.050a 0.434 ± 0.024a 0.400 ± 0.037a 7 0.036 ± 0.007 0.012 ± 0.001a 0.017 ± 0.003a 0.012 ± 0.002a 0.017 ± 0.001a 0.012 ± 0.002a 0.013 ± 0.003a 8 0.053 ± 0.020 0.151 ± 0.020a 0.136 ± 0.044a 0.146 ± 0.021a 0.137 ± 0.007a 0.140 ± 0.029a 0.140 ± 0.013a 9 0.038 ± 0.006 0.016 ± 0.004a 0.017 ± 0.003a 0.017 ± 0.003a 0.019 ± 0.007a 0.010 ± 0.008a 0.013 ± 0.007a 10 0.092 ± 0.028 0.257 ± 0.027a 0.245 ± 0.020a 0.228 ± 0.039a 0.219 ± 0.031a 0.264 ± 0.040a 0.214 ± 0.029a 11 0.098 ± 0.013 0.016 ± 0.004a 0.024 ± 0.006a 0.018 ± 0.003a 0.023 ± 0.003a 0.013 ± 0.004a 0.022 ± 0.004a 12 0.030 ± 0.003 0.189 ± 0.051a 0.158 ± 0.036a 0.