73m2BS (mL/min/1,73 m2Body Surface).6 Data with homogeneous distribution were shown as mean and standard deviation. All others were shown as median and range. Student’s t-test for paired samples was employed to compare variables with normal distribution, and the Wilcoxon test was used to compare non-normal distribution variables. The latter was also employed to compare the microalbuminuria levels before and after

the substitution of celecoxib to enalapril. The chi-squared test was used to compare the findings in UDE in symptomatic patients during indomethacin and celecoxib use. The study was approved by local ethics committee. Twenty patients were included, of whom 12 were females. Follow-up time was 10.1 ± 5.2 years, age at diagnosis had a median of 17.5 months (3–178) and at last evaluation was 14.0 ± 5.3 years. Five patients

were born from consanguineous parents and two patients were siblings. VX-809 solubility dmso Seven patients, five of whom females, presented with polyhydramnio and/or prematurity, characteristics of neonatal BS. Neurosensorial deafness was observed in two patients (one female), and they are classified as BS with deafness. Eleven patients showed characteristics of classic BS. No patient presented with hypocalciuria, thus excluding the diagnosis of Gitelman syndrome. Seventeen patients received indomethacin for 5.9 ± 5.3 years in a dosage of 2.1 ± 0.6 mg/Kg/day divided in three doses. An increase was observed in height-for-age selleck chemicals llc Z-score, from -3.3 ± -2.1 to -2.2 ± 1.2 (p = 0.01), and in weight-for-age Z-score, from median = -2.9 (-5.7 – 2.5) to median = -1.05 (-4.9- 2.5) (p = 0.0004), without a significant change in the creatinine clearance, which varied from crotamiton median

= 105 (64-277) to median = 144 (71-279) mL/min/1.73m2BS (p = 0.34); and with metabolic and electrolyte stability. However, four patients had hyperfiltration at the beginning and eight presented hyperfiltration at the end of the treatment. Seven of 17 patients had GI symptoms, and UDE evidenced gastritis in three cases and gastric ulcer, a severe finding, in four. Nineteen patients received celecoxib, during a median of 35 months (8-144). An increase was observed in height-for-age Z-score from -2.4 ± -1.7 to 1.8 ±1.3 (p = 0.02) and in weight-for-age Z-score from -1.3 ± 1.5 to -0.81 ± 1.2 (p = 0.01), as well as a reduction in creatinine clearance from 147 ± 52 to 119 ± 31 mL/min/1.73m2BS (p = 0.04). Nine patients presented with hyperfiltration at the beginning of treatment; at the end, hyperfiltration was detected in only two patients. Seven of 19 patients presented GI symptoms, but UDE evidenced mild gastritis in three cases and no case of ulcer. Comparing indomethacin with celecoxib, positive findings in UDE were more present in indomethacin group, although not significant (p = 0.06); however, indomethacin was associated with more severe compromise. During the treatment with celecoxib, no patient developed gastric ulcer.